ArticleProceedings of the National Academy of Sciences of the United States of America2006
Genome scan for cis-regulatory DNA motifs associated with social behavior in honey bees.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed.
- Evolutionary Transitions in Social Behavior are Associated With Convergent and Partially Reversible Expansions of Transcription Factor Binding Sites.Genome biology and evolution · 2026Article
- Effects of microRNA-305 knockdown on brain gene expression associated with division of labor in honey bee colonies (Apis mellifera).The Journal of experimental biology · 2024Article
- Individual differences in honey bee behavior enabled by plasticity in brain gene regulatory networks.eLife · 2020Article
- Behavior-related gene regulatory networks: A new level of organization in the brain.Proceedings of the National Academy of Sciences of the United States of America · 2020Review
- Transcriptional response of honey bee (Apis mellifera) to differential nutritional status and Nosema infection.BMC genomics · 2018Article
- The Impact of Environmental Mn Exposure on Insect Biology.Frontiers in genetics · 2018Review
- On the Molecular Basis of Division of Labor in Solenopsis invicta (Hymenoptera: Formicidae) Workers: RNA-seq Analysis.Journal of insect science (Online) · 2017Article
- Diet and endocrine effects on behavioral maturation-related gene expression in the pars intercerebralis of the honey bee brain.The Journal of experimental biology · 2015Article
- Insights into the Transcriptional Architecture of Behavioral Plasticity in the Honey Bee Apis mellifera.Scientific reports · 2015Article
- Bidirectional promoters of insects: genome-wide comparison, evolutionary implication and influence on gene expression.Journal of molecular biology · 2015Article
- RNAi-mediated double gene knockdown and gustatory perception measurement in honey bees (Apis mellifera).Journal of visualized experiments : JoVE · 2013Article
- Transcriptional regulation of brain gene expression in response to a territorial intrusion.Proceedings. Biological sciences · 2012Article
- Recombination is associated with the evolution of genome structure and worker behavior in honey bees.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- New meta-analysis tools reveal common transcriptional regulatory basis for multiple determinants of behavior.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The transcription factor ultraspiracle influences honey bee social behavior and behavior-related gene expression.PLoS genetics · 2012Article
- Mechanisms of stable lipid loss in a social insect.The Journal of experimental biology · 2011Article
- Reptiles and mammals have differentially retained long conserved noncoding sequences from the amniote ancestor.Genome biology and evolution · 2011Article
- Comparative analysis of expressed sequence tags from three castes and two life stages of the termite Reticulitermes flavipes.BMC genomics · 2010Article
- Functional characterization of transcription factor motifs using cross-species comparison across large evolutionary distances.PLoS computational biology · 2010Article
- Honey bee aggression supports a link between gene regulation and behavioral evolution.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
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5 authors.
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Abstract
Honey bees (Apis mellifera) undergo an age-related, socially regulated transition from working in the hive to foraging, which is associated with changes in the expression of thousands of genes in the brain. To begin to study the cis-regulatory code underlying this massive social regulation of gene expression, we used the newly sequenced honey bee genome to scan the promoter regions of eight sets of behaviorally related genes differentially expressed in the brain in the context of division of labor among worker bees, for 41 cis-regulatory motifs previously characterized in Drosophila melanogaster. Binding sites for the transcription factors Hairy, GAGA, Adf1, Cf1, Snail, and Dri, known to function in nervous system development, olfactory learning, or hormone binding in Drosophila, were significantly associated with one or more gene sets. The presence of some binding sites also predicted expression patterns for as many as 71% of the genes in some gene sets. These results suggest that there is a robust relationship between cis and social regulation of brain gene expression, especially considering that we studied <15% of all known transcription factors. These results also suggest that transcriptional networks involved in the regulation of development in Drosophila are used to regulate behavioral development in adult honey bees. However, differences in gene regulation between these two processes are suggested by the finding that the promoter regions for the behaviorally related bee genes differed in both motif occurrence and G/C content relative to their Drosophila orthologs.
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