Evidence map›Paper›PMID 17065275›Full record

Trial reportAmerican journal of epidemiology2007

Risk factors for umbilical cord infection among newborns of southern Nepal.

Luke C Mullany, Gary L Darmstadt, Joanne Katz, Subarna K Khatry, Steven C LeClerq, Ramesh K Adhikari, James M Tielsch

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of epidemiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00109616 (Newborn Antiseptic Washing and Neonatal Mortality-Nepal), which is not on this map. Cited by 52 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 7 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00109616 phase3completednot on this map

Newborn Antiseptic Washing and Neonatal Mortality-Nepal

TypeinterventionalSponsorEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Ran2002 to 2006Enrolled17,000ConditionsNeonatal MortalityArmsNewborn skin cleansing with 0.25% chlorhexidine solution, Cleansing of umbilical cord with soap and water solution, Cleansing of umbilical cord with 4% chlorhexidine
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 7 syntheses or guidelines pooled it, 137 citations in OpenAlex.

  1. Umbilical cord antiseptics for preventing sepsis and death among newborns.The Cochrane database of systematic reviews · 2026
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  4. Umbilical cord antiseptics for preventing sepsis and death among newborns.The Cochrane database of systematic reviews · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Luke C MullanyDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21211, USA. Lmullany@jhsph.edu
Gary L Darmstadt
Joanne Katz
Subarna K Khatry
Steven C LeClerq
Ramesh K Adhikari
James M Tielsch
Johns Hopkins University · USTribhuvan University · NP

Funding

ZINC SUPPLEMENTATION IMPACT ON CHILD MORTALITY--NEPALR01HD038753 · NICHD · JOHNS HOPKINS UNIVERSITY · PI TIELSCH, JAMES M · 2000 to 2003
$3.5M
Newborn Antiseptic Washing and Neonatal Mortality-NepalR01HD044004 · NICHD · JOHNS HOPKINS UNIVERSITY · PI TIELSCH, JAMES M · 2003 to 2005
$1.5M
NICHD NIH HHS HD38753NICHD NIH HHS HD44004NICHD NIH HHS R01 HD038753NICHD NIH HHS R01 HD044004
6 · The paper itself

Abstract

Although umbilical cord infection contributes to neonatal mortality and morbidity and risk can be reduced with topical chlorhexidine, behavioral or other factors associated with cord infection in low-resource settings have not been examined. Data on potential risk factors for omphalitis were collected during a community-based, umbilical cord care trial in Nepal during 2002-2005. Newborns were evaluated in the home for signs of umbilical cord infection (pus, redness, and swelling). Omphalitis was defined as either pus discharge with erythema of the abdominal skin or severe redness (>2 cm extension from the cord stump) with or without pus. Multivariable regression modeling was used to examine associations between omphalitis and maternal, newborn, and household variables. Omphalitis was identified in 954 of 17,198 newborns (5.5%). Infection risk was 29% and 62% higher in infants receiving topical cord applications of mustard oil and other potentially unclean substances, respectively. Skin-to-skin contact (relative risk (RR) = 0.64, 95% confidence interval (CI): 0.43, 0.95) and hand washing by birth attendants (RR = 0.73, 95% CI: 0.64, 0.84) and caretakers (RR = 0.76, 95% CI: 0.60, 0.95) were associated with fewer infections. In this community, unhygienic newborn-care practices lead to continued high risk for omphalitis. In addition to topical antiseptics, simple, low-cost interventions such as hand washing, skin-to-skin contact, and avoiding unclean cord applications should be promoted by community-based health workers.

Indexed as

Bacterial InfectionsConfidence IntervalsFemaleFollow-Up StudiesHumansInfant, NewbornMorbidityNepalPregnancyPrognosisRetrospective StudiesRisk FactorsUmbilical Cord

Identifiers

PMID17065275
PMCPMC2362499
OpenAlexW2119913531

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.