ArticleGenomics2007
Connexin43 and the brain transcriptome of newborn mice.
Article in Genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- Transcriptomic Challenges We Faced with Animal Models for Neurological Disorders.Current issues in molecular biology · 2026Review
- Characterization of Pannexin1, Connexin32, and Connexin43 in Spotted Sea Bass (Frontiers in immunology · 2022Article
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- Powerful quantifiers for cancer transcriptomics.World journal of clinical oncology · 2020Review
- Biomarkers, Master Regulators and Genomic Fabric Remodeling in a Case of Papillary Thyroid Carcinoma.Genes · 2020Article
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- Regeneration of neurotransmission transcriptome in a model of epileptic encephalopathy after antiinflammatory treatment.Neural regeneration research · 2018Review
- ACTH and PMX53 recover synaptic transcriptome alterations in a rat model of infantile spasms.Scientific reports · 2018Article
- Gene master regulators of papillary and anaplastic thyroid cancers.Oncotarget · 2018Article
- Estrogen Protects Neurotransmission Transcriptome During Status Epilepticus.Frontiers in neuroscience · 2018Article
- Prenatal corticosteroids modify glutamatergic and GABAergic synapse genomic fabric: insights from a novel animal model of infantile spasms.Journal of neuroendocrinology · 2013Review
- Plasticity of the myelination genomic fabric.Molecular genetics and genomics : MGG · 2012Article
- Immunophilin deficiency augments Ca2+-dependent glutamate release from mouse cortical astrocytes.Cell calcium · 2011Article
- The carboxyl-terminal domain of connexin43 is a negative modulator of neuronal differentiation.The Journal of biological chemistry · 2010Article
- Sex-dependent gene regulatory networks of the heart rhythm.Functional & integrative genomics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Our previously reported cDNA array datasets from neonatal wild-type and Cx43-/- (approved gene symbol Gja1) mouse brains were further analyzed to identify underlying interlinkages in the brain transcriptome. The analysis revealed that no gene cohort sharing either primary function or chromosomal location was significantly altered (up-and down-regulation were roughly balanced) in Cx43-/- brains, but each cohort exhibited significant perturbation of transcript abundance proportions and reduced expression variability and coordination. By comparing pairwise expression correlations of all genes with one another in wild-type brains, we found genes exhibiting remarkable similarity or opposition to the coordination profile (set of synergistically, antagonistically, and independently expressed partners) of Cx43, one of the most similar being pannexin1, a vertebrate homolog of invertebrate gap junction proteins. This study indicates striking redundancy of expression controls over functional pathways and suggests that certain genes may play roles similar to or opposite that of Cx43 in organizing the brain transcriptome.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.