ArticleCurrent infectious disease reports2006
Recent insights into the mechanisms of antifungal resistance.
Article in Current infectious disease reports, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Plant-Derived Substances in the Fight Against Infections Caused byInternational journal of molecular sciences · 2020Review
- Two small, cysteine-rich and cationic antifungal proteins from Penicillium chrysogenum: A comparative study of PAF and PAFB.Biochimica et biophysica acta. Biomembranes · 2020Review
- Known Antimicrobials Versus Nortriptyline inMicroorganisms · 2020Article
- Targeting the fungal cell wall: current therapies and implications for development of alternative antifungal agents.Future medicinal chemistry · 2019Review
- Exposure of Candida albicans β (1,3)-glucan is promoted by activation of the Cek1 pathway.PLoS genetics · 2019Article
- Identification and Mode of Action of a Plant Natural Product Targeting Human Fungal Pathogens.Antimicrobial agents and chemotherapy · 2017Article
- Synthesized zinc peroxide nanoparticles (ZnOInternational journal of nanomedicine · 2017Article
- Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species.Memorias do Instituto Oswaldo Cruz · 2016Article
- Ruta montana L. leaf essential oil and extracts: characterization of bioactive compounds and suppression of crown gall disease.EXCLI journal · 2015Article
- Carum copticum and Thymus vulgaris oils inhibit virulence in Trichophyton rubrum and Aspergillus spp.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2014Article
- Antifungal agents commonly used in the superficial and mucosal candidiasis treatment: mode of action and resistance development.Postepy dermatologii i alergologii · 2013Review
- RNA sequencing revealed novel actors of the acquisition of drug resistance in Candida albicans.BMC genomics · 2012Article
- Antifungal activity of four honeys of different types from Algeria against pathogenic yeast: Candida albicans and Rhodotorula sp.Asian Pacific journal of tropical biomedicine · 2012Article
- Identification and functional characterization of Rca1, a transcription factor involved in both antifungal susceptibility and host response in Candida albicans.Eukaryotic cell · 2012Article
- Evaluation of matrix-assisted laser desorption ionization-time of flight mass spectrometry for identification of clinically important yeast species.Journal of clinical microbiology · 2010Article
- Functional analysis of cis- and trans-acting elements of the Candida albicans CDR2 promoter with a novel promoter reporter system.Eukaryotic cell · 2009Article
- Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae.Antimicrobial agents and chemotherapy · 2009Article
- Modes of action of the new arylguanidine abafungin beyond interference with ergosterol biosynthesis and in vitro activity against medically important fungi.Chemotherapy · 2008Article
- Inhibition of fungal and bacterial plant pathogens in vitro and in planta with ultrashort cationic lipopeptides.Applied and environmental microbiology · 2007Article
- Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.Eukaryotic cell · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of fungal infections has increased in recent years, particularly among immunocompromised individuals. Treatment of invasive fungal infections has been hampered by a limited number of available antifungal agents and both intrinsic and acquired resistance to these agents among many fungal pathogens. Therefore, much interest has focused on elucidating the molecular basis for antifungal resistance. Recent efforts have increased our understanding of this process, including the transcriptional regulation of azole resistance in Candida spp, mechanisms of intrinsic resistance to amphotericin B, and mechanisms of acquired resistance to the new echinocandin class of antifungal agents. This review discusses these and other newly clarified resistance mechanisms, as well as the direction of future antifungal resistance research. Despite these advances, undiscovered resistance determinants exist, and resistance to newer agents likely will continue to emerge.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.