Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. The type 2 diabetes-associated variant in TCF7L2 is associated with latent autoimmune diabetes in adult Europeans and the gene effect is modified by obesity: a meta-analysis and an individual study.Diabetologia · 2012
   Pooled it
2. Clinical signs of type 1 diabetes are associated with type 2 diabetes marker transcription factor 7-like 2 polymorphism.Journal of diabetes investigation · 2023
   Article
3. Obesity in Patients with Type 1 Diabetes: Links, Risks and Management Challenges.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021
   Review
4. New Insights into the Genetics of Latent Autoimmune Diabetes in Adults.Current diabetes reports · 2020
   Review
5. TheDiabetes care · 2019
   Review
6. Latent Autoimmune Diabetes in Adults: A Review on Clinical Implications and Management.Diabetes & metabolism journal · 2018
   Review
7. Diabetes care · 2018
   Article
8. Genetic variation of the transcription factor GATA3, not STAT4, is associated with the risk of type 2 diabetes in the Bangladeshi population.PloS one · 2018
   Article
9. Latent autoimmune diabetes of the adult: current knowledge and uncertainty.Diabetic medicine : a journal of the British Diabetic Association · 2015
   Review
10. Type 2 diabetes susceptibility gene variants predispose to adult-onset autoimmune diabetes.Diabetologia · 2014
    Article
11. Overlap of genetic susceptibility to type 1 diabetes, type 2 diabetes, and latent autoimmune diabetes in adults.Current diabetes reports · 2014
    Review
12. Type 2 diabetes in childhood: clinical characteristics and role of β-cell autoimmunity.Current diabetes reports · 2012
    Review
13. Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes.PloS one · 2012
    Article
14. Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes.Diabetes · 2010
    Article
15. No association of multiple type 2 diabetes loci with type 1 diabetes.Diabetologia · 2009
    Article
16. Type 1 and type 2 diabetes-chalk and cheese?Diabetologia · 2009
    Article
17. Association of hypoxia inducible factor-1 alpha gene polymorphism with both type 1 and type 2 diabetes in a Caucasian (Hungarian) sample.BMC medical genetics · 2009
    Article
18. Genome-wide association studies in type 1 diabetes.Current diabetes reports · 2009
    Review
19. Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes.The Journal of clinical endocrinology and metabolism · 2009
    Article
20. Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.Diabetologia · 2008
    Article

Corrections and comments

• Commented on by
  The accelerator hypothesis cannot be tested using the type 2 diabetes gene, TCF7L2.2007

Authors and funding

6 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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