ReviewInterdisciplinary topics in gerontology2007
Secrets of the lac operon. Glucose hysteresis as a mechanism in dietary restriction, aging and disease.
Review in Interdisciplinary topics in gerontology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- Calorie Restriction Effects on Aging, Learning Performance, and Transcription in Aged Aplysia californica.Genes, brain, and behavior · 2026Article
- Inflammation and aging-related disease: A transdisciplinary inflammaging framework.GeroScience · 2025Review
- Signals of energy availability in sleep: consequences of a fat-based metabolism.Frontiers in nutrition · 2024Review
- Biological age and environmental risk factors for dementia and stroke: Molecular mechanisms.Frontiers in aging neuroscience · 2022Review
- Metabolic disorder in Alzheimer's disease.Metabolic brain disease · 2021Review
- Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction.Nature communications · 2020Article
- Metabolic transcriptional memory.Molecular metabolism · 2020Review
- Gluconeogenesis and PEPCK are critical components of healthy aging and dietary restriction life extension.PLoS genetics · 2020Article
- Observational
- Dietary Restriction and Glycolytic Inhibition Reduce Proteotoxicity and Extend Lifespan via NHR-49.Current neurobiology · 2018Article
- Glucose-Induced Transcriptional Hysteresis: Role in Obesity, Metabolic Memory, Diabetes, and Aging.Frontiers in endocrinology · 2018Review
- Retinol as a cofactor for PKCδ-mediated impairment of insulin sensitivity in a mouse model of diet-induced obesity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Article
- Caloric restriction and the aging process: a critique.Free radical biology & medicine · 2014Review
- A novel kinase regulates dietary restriction-mediated longevity in Caenorhabditis elegans.Aging cell · 2014Article
- Metabolic mystery: aging, obesity, diabetes, and the ventromedial hypothalamus.Trends in endocrinology and metabolism: TEM · 2013Article
- Age increase of estrogen receptor-α (ERα) in cortical astrocytes impairs neurotrophic support in male and female rats.Endocrinology · 2013Article
- Role of the hypothalamus in mediating protective effects of dietary restriction during aging.Frontiers in neuroendocrinology · 2013Review
- Regulation of peripheral metabolism by substrate partitioning in the brain.Endocrinology and metabolism clinics of North America · 2013Review
- Ketone bodies protection against HIV-1 Tat-induced neurotoxicity.Journal of neurochemistry · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Elevated blood glucose associated with diabetes produces progressive and apparently irreversible damage to many cell types. Conversely, reduction of glucose extends life span in yeast, and dietary restriction reduces blood glucose. Therefore it has been hypothesized that cumulative toxic effects of glucose drive at least some aspects of the aging process and, conversely, that protective effects of dietary restriction are mediated by a reduction in exposure to glucose. The mechanisms mediating cumulative toxic effects of glucose are suggested by two general principles of metabolic processes, illustrated by the lac operon but also observed with glucose-induced gene expression. First, metabolites induce the machinery of their own metabolism. Second, induction of gene expression by metabolites can entail a form of molecular memory called hysteresis. When applied to glucose-regulated gene expression, these two principles suggest a mechanism whereby repetitive exposure to postprandial excursions of glucose leads to an age-related increase in glycolytic capacity (and reduction in beta-oxidation of free fatty acids), which in turn leads to an increased generation of oxidative damage and a decreased capacity to respond to oxidative damage, independent of metabolic rate. According to this mechanism, dietary restriction increases life span and reduces pathology by reducing exposure to glucose and therefore delaying the development of glucose-induced glycolytic capacity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.