ArticleBMC genomics2006
Comparative genomics of vertebrate Fox cluster loci.
Article in BMC genomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- The Fox Gene Repertoire in the Annelid Owenia fusiformis Reveals Multiple Expansions of the foxQ2 Class in Spiralia.Genome biology and evolution · 2022Article
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- Human FoxP Transcription Factors as Tractable Models of the Evolution and Functional Outcomes of Three-Dimensional Domain Swapping.International journal of molecular sciences · 2021Review
- Article
- FOXS1 is regulated by GLI1 and miR-125a-5p and promotes cell proliferation and EMT in gastric cancer.Scientific reports · 2019Article
- Chromosome evolution at the origin of the ancestral vertebrate genome.Genome biology · 2018Article
- Genome-Wide Identification and Characterization of Fox Genes in the Honeybee,International journal of genomics · 2018Article
- Genome-wide identification, phylogeny, and gonadal expression of fox genes in Nile tilapia, Oreochromis niloticus.Fish physiology and biochemistry · 2014Article
- Critical physiological and pathological functions of Forkhead Box O tumor suppressors.Discoveries (Craiova, Romania) · 2013Review
- Cytochrome c oxidase: evolution of control via nuclear subunit addition.Biochimica et biophysica acta · 2012Review
- The Role of FoxC2 Transcription Factor in Tumor Angiogenesis.Journal of oncology · 2012Article
- Evolution of the couple cytochrome c and cytochrome c oxidase in primates.Advances in experimental medicine and biology · 2012Review
- Global characterization of interferon regulatory factor (IRF) genes in vertebrates: glimpse of the diversification in evolution.BMC immunology · 2010Article
- Conservation of gene linkage in dispersed vertebrate NK homeobox clusters.Development genes and evolution · 2009Article
- The Fox genes of Branchiostoma floridae.Development genes and evolution · 2008Article
- Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates.BMC evolutionary biology · 2008Article
- Phylogenomic analyses of KCNA gene clusters in vertebrates: why do gene clusters stay intact?BMC evolutionary biology · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundVertebrate genomes contain numerous duplicate genes, many of which are organised into paralagous regions indicating duplication of linked groups of genes. Comparison of genomic organisation in different lineages can often allow the evolutionary history of such regions to be traced. A classic example of this is the Hox genes, where the presence of a single continuous Hox cluster in amphioxus and four vertebrate clusters has allowed the genomic evolution of this region to be established. Fox transcription factors of the C, F, L1 and Q1 classes are also organised in clusters in both amphioxus and humans. However in contrast to the Hox genes, only two clusters of paralogous Fox genes have so far been identified in the Human genome and the organisation in other vertebrates is unknown.
resultsTo uncover the evolutionary history of the Fox clusters, we report on the comparative genomics of these loci. We demonstrate two further paralogous regions in the Human genome, and identify orthologous regions in mammalian, chicken, frog and teleost genomes, timing the duplications to before the separation of the actinopterygian and sarcopterygian lineages. An additional Fox class, FoxS, was also found to reside in this duplicated genomic region.
conclusionComparison of loci identifies the pattern of gene duplication, loss and cluster break up through multiple lineages, and suggests FoxS1 is a likely remnant of Fox cluster duplication.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.