ArticlePsychopharmacology2007
Differential effects of nicotinic antagonists perfused into the nucleus accumbens or the ventral tegmental area on cocaine-induced dopamine release in the nucleus accumbens of mice.
Article in Psychopharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- The potential effect of α7 nicotinic receptors modulation on palatable food-induced dependence-like behaviors.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Article
- α4β2 Nicotinic receptor desensitizing compounds can decrease self-administration of cocaine and methamphetamine in rats.European journal of pharmacology · 2019Article
- Cocaine Directly Inhibits α6-Containing Nicotinic Acetylcholine Receptors in Human SH-EP1 Cells and Mouse VTA DA Neurons.Frontiers in pharmacology · 2019Article
- Cholinergic Interneurons Underlie Spontaneous Dopamine Release in Nucleus Accumbens.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Intra-ventral tegmental area microinjections of urotensin II modulate the effects of cocaine.Behavioural brain research · 2015Article
- Differential roles of α6β2* and α4β2* neuronal nicotinic receptors in nicotine- and cocaine-conditioned reward in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Effects of the nicotinic acetylcholine receptor antagonist mecamylamine on the discriminative stimulus effects of cocaine in male rhesus monkeys.Experimental and clinical psychopharmacology · 2014Article
- 1H-Nuclear magnetic resonance-based metabolomic analysis of brain in mice with nicotine treatment.BMC neuroscience · 2014Article
- Differential role of ventral tegmental area acetylcholine and N-methyl-D-aspartate receptors in cocaine-seeking.Neuropharmacology · 2013Article
- The stereotypy-inducing and OCD-like effects of chronic 'binge' cocaine are modulated by distinct subtypes of nicotinic acetylcholine receptors.British journal of pharmacology · 2012Article
- The Hepatocyte Growth Factor/c-Met Antagonist, Divalinal-Angiotensin IV, Blocks the Acquisition of Methamphetamine Dependent Conditioned Place Preference in Rats.Brain sciences · 2012Article
- Cholinergic modulation of food and drug satiety and withdrawal.Physiology & behavior · 2012Review
- Recent advances in understanding nicotinic receptor signaling mechanisms that regulate drug self-administration behavior.Biochemical pharmacology · 2011Review
- Cholinergic modulation of mesolimbic dopamine function and reward.Physiology & behavior · 2011Review
- Drug discrimination in methamphetamine-trained rats: effects of cholinergic nicotinic compounds.The Journal of pharmacology and experimental therapeutics · 2010Article
- Mechanisms involved in systemic nicotine-induced glutamatergic synaptic plasticity on dopamine neurons in the ventral tegmental area.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Nicotinic acetylcholine receptors in the mesolimbic pathway: primary role of ventral tegmental area alpha6beta2* receptors in mediating systemic nicotine effects on dopamine release, locomotion, and reinforcement.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Self-administration of cocaine and nicotine mixtures by rhesus monkeys.Psychopharmacology · 2009Article
- Effects of subunit selective nACh receptors on operant ethanol self-administration and relapse-like ethanol-drinking behavior.Psychopharmacology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
rationaleThe mesolimbic dopamine (DA) system is considered a principal site for nicotine-cocaine interactions. OBJECTIVES AND
methodsThe aim of this paper is to study the effects of local perfusions (through the microdialysis cannula) of nicotinic acetylcholine receptor (nAChR) antagonists in the ventral tegmental area (VTA, where mesolimbic DA cell bodies are located) or nucleus accumbens (nAc, where mesolimbic DA nerve terminals project) on cocaine-elicited increase in DA levels in the nAc of mice using intracerebral microdialysis.
resultsIntra-nAc perfusion of mecamylamine (a nonselective central nicotinic antagonist) or coperfusion of methyllycaconitine (MLA, 10 nM) and dihydro-beta-erythroidine (DHbetaE, 10-100 muM) decreased cocaine-elicited increase in DA perfusate levels. In contrast, intra-nAc perfusion of MLA alone (a relatively selective antagonist of alpha7 subunit-containing nAChRs) increased, while DHbetaE (a relatively selective antagonist of heteromeric nAChR subtypes) did not alter, cocaine-elicited increase in DA perfusate levels. Intra-VTA perfusion of MLA (100 nM) or DHbetaE (100 micro M) significantly increased the cocaine-elicited increase of DA levels in the nAc or VTA, whereas DHbetaE and MLA coperfusion or mecamylamine perfusion had no significant effect.
conclusionsThese results show that intra-nAc and intra-VTA perfusion of nAChR antagonists differentially affect cocaine-elicited increase in DA levels in a region and subtype-specific manner. This suggests that multiple cholinergic/nicotinic pathways influence the effects of cocaine on mesolimbic DA neurons in complex, and sometimes opposing, patterns.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.