Evidence map›Paper›PMID 17060763›Full record

Trial reportAnnals of surgery2006

Perioperative synbiotic treatment to prevent postoperative infectious complications in biliary cancer surgery: a randomized controlled trial.

Gen Sugawara, Masato Nagino, Hideki Nishio, Tomoki Ebata, Kenji Takagi, Takashi Asahara, Koji Nomoto, Yuji Nimura

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of surgery, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01683708 (Effectiveness of Perioperative Symbiotic Therapy to Reduce Infectious Morbidity in Jaundiced Patients), which is not on this map. Cited by 123 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 14 pooled it
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01683708 unknown statusnot on this mapstarted 2008, after this paper: background citation

Effectiveness of Perioperative Symbiotic Therapy to Reduce Infectious Morbidity in Jaundiced Patients: a Randomized Controlled Trial

TypeobservationalSponsorAzienda Ospedaliera Ordine Mauriziano di TorinoRan2008Enrolled20ConditionsPostoperative Infections, JaundiceArmsSymbiotic therapy
3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 14 syntheses or guidelines pooled it, 343 citations in OpenAlex.

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  11. Methods of decreasing infection to improve outcomes after liver resections.The Cochrane database of systematic reviews · 2011
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63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Gen SugawaraDivision of Surgical Oncology, Department of Surgery; Nagoya University Graduate School of Medicine, Nagoya, Japan.
Masato Nagino
Hideki Nishio
Tomoki Ebata
Kenji Takagi
Takashi Asahara
Koji Nomoto
Yuji Nimura
Yakult Central Institute · JPNagoya University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

summary background dataUse of synbiotics has been reported to benefit human health, but clinical value in surgical patients remains unclear.

objectiveTo investigate the effect of perioperative oral administration of synbiotics upon intestinal barrier function, immune responses, systemic inflammatory responses, microflora, and surgical outcome in patients undergoing high-risk hepatobiliary resection.

methodsPatients with biliary cancer involving the hepatic hilus (n = 101) were randomized before hepatectomy, into a group receiving postoperative enteral feeding with synbiotics (group A); or another receiving preoperative plus postoperative synbiotics (group B). Lactulose-mannitol (L/M) ratio, serum diamine oxidase (DAO) activity, natural killer (NK) cell activity, interleukin-6 (IL-6), fecal microflora, and fecal organic acid concentrations were determined before and after hepatectomy. Postoperative infectious complications were recorded.

resultsOf 101 patients, 81 completed the trial. Preoperative and postoperative changes in L/M ratio and DAO activity were similar between groups. Preoperatively in group B, NK activity, and lymphocyte counts increased, while IL-6 decreased significantly (P < 0.05). Postoperative serum IL-6, white blood cell counts, and C-reactive protein in group B were significantly lower than in group A (P < 0.05). During the preoperative period, numbers of Bifidobacterium colonies cultured from and total organic acid concentrations measured in feces increased significantly in group B (P < 0.05). Postoperative concentrations of total organic acids and acetic acid in feces were significantly higher in group B than in group A (P < 0.05). Incidence of postoperative infectious complications was 30.0% (12 of 40) in group A and 12.1% (5 of 41) in group B (P < 0.05).

conclusionsPreoperative oral administration of synbiotics can enhance immune responses, attenuate systemic postoperative inflammatory responses, and improve intestinal microbial environment. These beneficial effects likely reduce postoperative infectious complications after hepatobiliary resection for biliary tract cancer.

Indexed as

HepatectomyHepatic Duct, CommonAmine Oxidase (Copper-Containing)BifidobacteriumBile Duct NeoplasmsEnzyme-Linked Immunosorbent AssayFecesFemaleFollow-Up StudiesHumansInterleukin-6Killer Cells, NaturalLacticaseibacillus caseiMaleMiddle AgedPerioperative CareAmine Oxidase (Copper-Containing)Interleukin-6

Identifiers

PMID17060763
PMCPMC1856608
OpenAlexW2110284028

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.