ArticleProceedings of the National Academy of Sciences of the United States of America2006
Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.Leukemia · 2016Article
- A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy.Oncotarget · 2014Article
- LANA binds to multiple active viral and cellular promoters and associates with the H3K4methyltransferase hSET1 complex.PLoS pathogens · 2014Article
- Mixl1 localizes to putative axial stem cell reservoirs and their posterior descendants in the mouse embryo.Gene expression patterns : GEP · 2014Article
- Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia.Genes & development · 2012Article
- The preleukemic state of mice reconstituted with Mixl1-transduced marrow cells.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Clonogenic mast cell progenitors and their excess numbers in chimeric BALB/c mice with inactivated GATA-1.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mixl1, the sole murine homologue of the Xenopus Mix/Bix family of homeobox transcription factors, is essential for the patterning of axial mesendodermal structures during early embryogenesis. Gene targeting and overexpression studies have implicated Mixl1 as a regulator of hematopoiesis arising in differentiating embryonic stem cells. To assess the role of Mixl1 in the regulation of adult hematopoiesis, we overexpressed Mixl1 in murine bone marrow using a retroviral transduction/transplantation model. Enforced expression of Mixl1 profoundly perturbed hematopoietic lineage commitment and differentiation, giving rise to abnormal myeloid progenitors and impairing erythroid and lymphoid differentiation. Moreover, all mice reconstituted with Mixl1-transduced bone marrow developed fatal, transplantable acute myeloid leukemia with a mean latency period of 200 days. These observations establish a link between enforced Mixl1 expression and leukemogenesis in the mouse.
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Registered trials
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