Evidence map›Paper›PMID 17060337›Full record

ArticleBMJ (Clinical research ed.)2006

Statins and outcomes in patients admitted to hospital with community acquired pneumonia: population based prospective cohort study.

Sumit R Majumdar, Finlay A McAlister, Dean T Eurich, Raj S Padwal, Thomas J Marrie

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ (Clinical research ed.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00528580 (Statins for the Early Treatment of Sepsis), which is not on this map. Cited by 109 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00528580 phase2terminatednot on this mapstarted 2008, after this paper: background citation

Statins for the Early Treatment of Sepsis

TypeinterventionalSponsorUniversity of ChicagoRan2008 to 2011Enrolled68ConditionsSepsisArmsSimvastatin, Identical-appearing placebo
3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  12. The effect of rosuvastatin on incident pneumonia: results from the JUPITER trial.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2012 · on this map
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  14. Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers.American journal of respiratory and critical care medicine · 2009
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49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Sumit R MajumdarDepartment of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. me2.majumdar@ualberta.ca
Finlay A McAlister
Dean T Eurich
Raj S Padwal
Thomas J Marrie

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine whether statins reduce mortality or need for admission to intensive care in patients admitted to hospital with community acquired pneumonia; and to assess whether previously reported improvements in sepsis related outcomes were a result of the healthy user effect.

designPopulation based prospective cohort study.

settingSix hospitals in Capital Health, Edmonton, Alberta, Canada.

participantsAdults admitted to hospital with pneumonia and categorised according to use of statins for at least one week before admission and during hospital stay.

main outcome measuresComposite of in-hospital mortality or admission to an intensive care unit.

resultsOf 3415 patients with pneumonia admitted to hospital, 624 (18%) died or were admitted to an intensive care unit. Statin users were less likely to die or be admitted to an intensive care unit than non-users (50/325 (15%) v 574/3090 (19%), odds ratio 0.80, P=0.15). After more complete adjustment for confounding, however, the odds ratios changed from potential benefit (0.78, adjusted for age and sex) to potential harm (1.10, fully adjusted including propensity scores, 95% confidence interval 0.76 to 1.60).

conclusionsStatins are not associated with reduced mortality or need for admission to an intensive care unit in patients with pneumonia; reports of benefit in the setting of sepsis may be a result of confounding.

Indexed as

AgedAlbertaCohort StudiesCommunity-Acquired InfectionsFemaleHealthy Worker EffectHospitalizationHospital MortalityHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMalePneumonia, BacterialProspective StudiesRegression AnalysisTreatment OutcomeHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID17060337
PMCPMC1635620

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.