Trial reportBMJ (Clinical research ed.)2006
Prophylactic antibiotics to prevent pneumonia and other complications after measles: community based randomised double blind placebo controlled trial in Guinea-Bissau.
Trial report in BMJ (Clinical research ed.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT00168532 (Prophylactic Antibiotics in Measles Infection. A Community-Based Randomised Double-Blind Placebo-Controlled Trial in Guinea-Bissau), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prophylactic Antibiotics in Measles Infection. A Community-Based Randomised Double-Blind Placebo-Controlled Trial in Guinea-Bissau
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Antibiotics for preventing complications in children with measles.The Cochrane database of systematic reviews · 2013Pooled it
- Do children with uncomplicated severe acute malnutrition need antibiotics? A systematic review and meta-analysis.PloS one · 2013Pooled it
- Daily co-trimoxazole prophylaxis to prevent mortality in children with complicated severe acute malnutrition: a multicentre, double-blind, randomised placebo-controlled trial.The Lancet. Global health · 2016Trial
- Machine Learning Models for High-Throughput Screening of Obesogens Based on Pathway Network.Environment & health (Washington, D.C.) · 2026Article
- Clinical and Demographic Characteristics of Hospitalized Pediatric Measles Cases; The 2023 Outbreak in Northern Jordan.Infection and drug resistance · 2025Article
- Evaluation of Microbiota and Weight Alterations After the Administration of Tetracycline and Lactobacillus gasseri in Rats.Current microbiology · 2020Article
- Importance of gut microbiota in obesity.European journal of clinical nutrition · 2019Review
- Overuse of antimicrobials and over-hospitalization in an adult measles cluster in the Florence area during the ongoing Italian outbreak.Infection · 2018Article
- Prevention of antibiotic-associated metabolic syndrome in mice by intestinal alkaline phosphatase.Diabetes, obesity & metabolism · 2016Article
- Severe acute malnutrition and infection.Paediatrics and international child health · 2014Review
- The role of the manipulation of the gut microbiota in obesity.Current infectious disease reports · 2013Article
- [The role of atypical microorganisms and viruses in severe acute community-acquired pneumonia].Reanimation : journal de la Societe de reanimation de langue francaise · 2013Article
- Effective treatment strategies for paediatric community-acquired pneumonia.Expert opinion on pharmacotherapy · 2007Review
- Measles in developing countries.BMJ (Clinical research ed.) · 2006Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether prophylactic antibiotics can prevent complications of measles.
designCommunity based, randomised, double blind, placebo controlled trial.
settingBandim Health Project study area in Bissau, Guinea-Bissau, west Africa.
participants84 patients with measles during a measles epidemic in Bissau in 1998 (fewer than originally planned owing to interruption by war).
interventionsSulfamethoxazole-trimethoprim (co-trimoxazole) or placebo for seven days.
main outcome measuresPneumonia and admission to hospital. Also weight change during the first month of infection, diarrhoea, severe fever, oral thrush, stomatitis, conjunctivitis, and otitis media.
resultsThe median age of the patients with measles was 5.4 (range 0.49-24.8) years. One of 46 participants who received co-trimoxazole developed pneumonia, in contrast to six of 38 participants who received placebo (odds ratio 0.08 (95% confidence interval 0 to 0.56), adjusted for age group). The number needed to treat was 7 (4 to 48). All three participants admitted to hospital had received placebo (P=0.09). The weight gain during the first month after inclusion was 15 (2-29) g/day in the placebo group and 32 (23-42) g/day in the co-trimoxazole group (P=0.04, adjusted for age group, weight for age at inclusion, measles vaccination status, and duration of disease). Significantly less conjunctivitis occurred among recipients of co-trimoxazole than placebo, as well as a non-significant tendency to less diarrhoea, severe fever, oral thrush, and stomatitis. Complications of otitis media were the same in the two groups.
conclusionsThe group that received prophylactic antibiotics had less pneumonia and conjunctivitis and had significantly higher weight gains in the month after inclusion. The results indicate that prophylactic antibiotics may have an important role in the management of measles infection in low income countries.
trial registrationClinical trials NCT00168532.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.