ArticleJournal of thrombosis and haemostasis : JTH2006
Protective role of protein C inhibitor in monocrotaline-induced pulmonary hypertension.
Article in Journal of thrombosis and haemostasis : JTH, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Potential impact of serpin peptidase inhibitor clade (A) member 4 SERPINA4 (rs2093266) and SERPINA5 (rs1955656) genetic variants on COVID-19 induced acute kidney injury.Human gene (Amsterdam, Netherlands) · 2022Article
- The Serpin Superfamily and Their Role in the Regulation and Dysfunction of Serine Protease Activity in COPD and Other Chronic Lung Diseases.International journal of molecular sciences · 2021Review
- Angiotensin-(1-9) ameliorates pulmonary arterial hypertensionThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2018Article
- Effects of Single Drug and Combined Short-term Administration of Sildenafil, Pimobendan, and Nicorandil on Right Ventricular Function in Rats With Monocrotaline-induced Pulmonary Hypertension.Journal of cardiovascular pharmacology · 2015Article
- Effect of thrombomodulin on the development of monocrotaline-induced pulmonary hypertension.Journal of anesthesia · 2014Article
- Diaphragm atrophy and contractile dysfunction in a murine model of pulmonary hypertension.PloS one · 2013Article
- Pulmonary oxidative stress is increased in cyclooxygenase-2 knockdown mice with mild pulmonary hypertension induced by monocrotaline.PloS one · 2011Article
- Expression patterns of protein C inhibitor in mouse development.Journal of molecular histology · 2010Article
- Intracellular and extracellular serpins modulate lung disease.Journal of perinatology : official journal of the California Perinatal Association · 2008Review
- Serpins in thrombosis, hemostasis and fibrinolysis.Journal of thrombosis and haemostasis : JTH · 2007Review
- Is protein C inhibitor antithrombotic and protective in pulmonary hypertension?Journal of thrombosis and haemostasis : JTH · 2006Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProtein C inhibitor (PCI) plays a role in multiple biological processes including fertilization, coagulation, fibrinolysis and kinin systems.
objectivesWe hypothesized that PCI participates in the pathogenesis of pulmonary hypertension. To demonstrate this, we compared the development of pulmonary hypertension in mice overexpressing PCI in the lung with wild-type (WT) mice. Pulmonary hypertension was induced by s.c. injection of 600 mg kg-1 of monocrotaline weekly for 8 weeks.
resultsRight ventricular arterial pressure was significantly increased in monocrotaline-treated WT mice compared with that in monocrotaline-treated transgenic mice. Bronchoalveolar lavage fluid (BALF) levels of thrombin-antithrombin complex, monocyte chemoattractant protein-1 and platelet-derived growth factor, and the plasma level of tumor necrosis factor-alpha were significantly increased in monocrotaline-treated WT mice as compared with monocrotaline-treated PCI transgenic mice. Increased level of PCI-thrombin complex was detected in BALF from monocrotaline-treated PCI transgenic mice as compared with saline-treated PCI transgenic mice.
conclusionsThis study showed that increased expression of PCI in the lung is protective against monocrotaline-induced pulmonary hypertension, suggesting a potential beneficial effect of PCI for the therapy of this disease.
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