ArticleJournal of neurobiology2006
Developmental regulation of sensory axon regeneration in the absence of growth cones.
Article in Journal of neurobiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- SARM1 Suppresses Axon Branching Through Attenuation of Axonal Cytoskeletal Dynamics.Frontiers in molecular neuroscience · 2022Article
- The bioenergetics of neuronal morphogenesis and regeneration: Frontiers beyond the mitochondrion.Developmental neurobiology · 2020Review
- Mechanisms of Axon Elongation Following CNS Injury: What Is Happening at the Axon Tip?Frontiers in cellular neuroscience · 2020Article
- Harnessing cAMP signaling in musculoskeletal regenerative engineering.Drug discovery today · 2017Review
- Protein synthetic machinery and mRNA in regenerating tips of spinal cord axons in lamprey.The Journal of comparative neurology · 2016Article
- Drebrin coordinates the actin and microtubule cytoskeleton during the initiation of axon collateral branches.Developmental neurobiology · 2016Article
- Actin filament-microtubule interactions in axon initiation and branching.Brain research bulletin · 2016Review
- The dynein inhibitor Ciliobrevin D inhibits the bidirectional transport of organelles along sensory axons and impairs NGF-mediated regulation of growth cones and axon branches.Developmental neurobiology · 2015Article
- Antisense Morpholino Oligonucleotides Reduce Neurofilament Synthesis and Inhibit Axon Regeneration in Lamprey Reticulospinal Neurons.PloS one · 2015Article
- Activation of PI3K and R-Ras signaling promotes the extension of sensory axons on inhibitory chondroitin sulfate proteoglycans.Developmental neurobiology · 2014Article
- The kinesin-2 family member KIF3C regulates microtubule dynamics and is required for axon growth and regeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Angioneural crosstalk in scaffolds with oriented microchannels for regenerative spinal cord injury repair.Journal of molecular neuroscience : MN · 2013Article
- Nerve growth factor-induced formation of axonal filopodia and collateral branches involves the intra-axonal synthesis of regulators of the actin-nucleating Arp2/3 complex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Scar-mediated inhibition and CSPG receptors in the CNS.Experimental neurology · 2012Review
- Sensory Axon Regeneration: A Review from an in vivo Imaging Perspective.Experimental neurobiology · 2012Article
- The emerging role of forces in axonal elongation.Progress in neurobiology · 2011Review
- In vivo imaging of dorsal root regeneration: rapid immobilization and presynaptic differentiation at the CNS/PNS border.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Slowing of axonal regeneration is correlated with increased axonal viscosity during aging.BMC neuroscience · 2010Article
- A chemical screen identifies novel compounds that overcome glial-mediated inhibition of neuronal regeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Caenorhabditis elegans neuronal regeneration is influenced by life stage, ephrin signaling, and synaptic branching.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The actin filament (F-actin) cytoskeleton is thought to be required for normal axon extension during embryonic development. Whether this is true of axon regeneration in the mature nervous system is not known, but a progressive simplification of growth cones during development has been described and where specifically investigated, mature spinal cord axons appear to regenerate without growth cones. We have studied the cytoskeletal mechanisms of axon regeneration in developmentally early and late chicken sensory neurons, at embryonic day (E) 7 and 14 respectively. Depletion of F-actin blocked the regeneration of E7 but not E14 sensory axons in vitro. The differential sensitivity of axon regeneration to the loss of F-actin and growth cones correlated with endogenous levels of F-actin and growth cone morphology. The growth cones of E7 axons contained more F-actin and were more elaborate than those of E14 axons. The ability of E14 axons to regenerate in the absence of F-actin and growth cones was dependent on microtubule tip polymerization. Importantly, while the regeneration of E7 axons was strictly dependent on F-actin, regeneration of E14 axons was more dependent on microtubule tip polymerization. Furthermore, E14 axons exhibited altered microtubule polymerization relative to E7, as determined by imaging of microtubule tip polymerization in living neurons. These data indicate that the mechanism of axon regeneration undergoes a developmental switch between E7 and E14 from strict dependence on F-actin to a greater dependence on microtubule polymerization. Collectively, these experiments indicate that microtubule polymerization may be a therapeutic target for promoting regeneration of mature neurons.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.