ArticleInternational journal of clinical oncology2006
Detection and evaluation of epithelial cells in the blood of colon cancer patients using RT-PCR.
Article in International journal of clinical oncology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Circulating Tumour Cells as Prognostic Biomarkers in Colorectal Cancer: A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Prognostic significance of circulating tumour cells following surgical resection of colorectal cancers: a systematic review.British journal of cancer · 2010Pooled it
- Hydroxyethyl starch 200/0.5 decreases circulating tumor cells of colorectal cancer patients and reduces metastatic potential of colon cancer cell line through inhibiting platelets activation.Medical oncology (Northwood, London, England) · 2015Trial
- Recent advances in microfluidic methods in cancer liquid biopsy.Biomicrofluidics · 2019Review
- Common molecular markers between circulating tumor cells and blood exosomes in colorectal cancer: a systematic and analytical review.Cancer management and research · 2019Article
- Cytokeratin 17 mRNA as a prognostic marker of oral squamous cell carcinoma.Oncology letters · 2017Article
- CK20 mRNA Expression in Serum as a Biomarker for Colorectal Cancer Diagnosis: A Meta-analysis.Open medicine (Warsaw, Poland) · 2017Article
- Change in number and size of circulating tumor cells with high telomerase activity during treatment of patients with gastric cancer.Oncology letters · 2016Article
- Cytokeratin-20 and Survivin-Expressing Circulating Tumor Cells Predict Survival in Metastatic Colorectal Cancer Patients by a Combined Immunomagnetic qRT-PCR Approach.Molecular cancer therapeutics · 2015Article
- Molecular biomarkers for the detection of metastatic colorectal cancer cells.World journal of gastroenterology · 2014Review
- Prognostic significance of isolated tumor cells in patients with colorectal cancer in recent 10-year studies.Molecular and clinical oncology · 2013Review
- Prognostic impact of detecting viable circulating tumour cells in gastric cancer patients using a telomerase-specific viral agent: a prospective study.BMC cancer · 2012Article
- Clinical significance of CDX2-positive circulating tumour cells in colorectal cancer patients.British journal of cancer · 2011Article
- Multiplex RT-PCR-based detections of CEA, CK20 and EGFR in colorectal cancer patients.World journal of gastroenterology · 2010Article
- The human keratins: biology and pathology.Histochemistry and cell biology · 2008Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs a mode of colorectal cancer recurrence, liver metastasis plays an important role. One of the factors reported to predict liver metastasis is the detection of trace amounts of tumor cells in the blood. For this purpose, cancer cell-induced cytokeratins (CKs) are generally identified, using the reverse transcriptase-polymerase chain reaction (RT-PCR). In the present study, we aimed to detect trace amounts of tumor cells, based on CK20, in the circulating venous blood, and we examined pathological factors, liver metastasis, and prognosis.
methodsThe subjects were 57 colorectal cancer patients who had undergone operation. We examined the cancer-induced marker (CK20) in circulating venous blood by RT-PCR and investigated the relationships between this marker, pathological factors, and prognosis.
resultsDetection ratio of CK20 mRNA was 42.1%, and CK20 was significantly correlated with the pathological factor of lymph node metastasis (P = 0.037). The 5-year survival rate for CK20-positive patients was 62.5% and that for the CK20-negative patients was 87.5%; there was a significant difference (P = 0.048) between the two groups. Recurrence was recognized in six patients; two were positive for CK20 and four were negative for CK20.
conclusionsThese findings indicate that CK20 is strongly related to lymph node metastasis and prognosis, suggesting its usefulness for the diagnosis of colorectal cancer recurrence. However, CK20 did not predict liver metastasis.
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