Evidence map›Paper›PMID 17058100›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2007

The treatment of depression in cancer patients: a systematic review.

Gary Rodin, Nancy Lloyd, Mark Katz, Esther Green, Jean A Mackay, Rebecca K S Wong, Supportive Care Guidelines Group of Cancer Care Ontario Program in Evidence-Based Care

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01497548 (A Parallel-group, Double-blind, Placebo-controlled Study of Methylphenidate as an Add on Therapy for Mirtazapine in the Treatment of Major Depressive Disorder in Cancer Patients Under Palliative Care), which is not on this map. Cited by 54 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 13 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01497548 phase3unknown statusnot on this mapstarted 2011, after this paper: background citation

A Parallel-group, Double-blind, Placebo-controlled Study of Methylphenidate as an Add on Therapy for Mirtazapine in the Treatment of Major Depressive Disorder in Cancer Patients Under Palliative Care

TypeinterventionalSponsorUniversity of MalayaRan2011 to 2012Enrolled120ConditionsDepressionArmsMethylphenidate, Placebo
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 13 syntheses or guidelines pooled it, 204 citations in OpenAlex.

  1. The effectiveness of mindfulness-based interventions among cancer patients and survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Pooled it
  2. Antidepressants for the treatment of depression in people with cancer.The Cochrane database of systematic reviews · 2018
    Pooled it
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  5. Antidepressants for the treatment of depression in people with cancer.The Cochrane database of systematic reviews · 2015
    Pooled it
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  11. Evidence for interventions to improve psychological outcomes in people with head and neck cancer: a systematic review of the literature.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2011
    Pooled it
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  19. Slow versus standard up-titration of paroxetine for the treatment of depression in cancer patients: a pilot study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2012
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Gary RodinDepartment of Psychosocial Oncology and Palliative Care, Princess Margaret Hospital, Toronto, ON, Canada. gary.rodin@uhn.on.ca
Nancy Lloyd
Mark Katz
Esther Green
Jean A Mackay
Rebecca K S Wong
Supportive Care Guidelines Group of Cancer Care Ontario Program in Evidence-Based Care
Cancer Care Ontario · CAMcMaster University · CAPrincess Margaret Cancer Centre · CAPrincess Margaret Hospital · NZSouthlake Regional Health Center · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

goals of the workTo evaluate the efficacy of pharmacological and nonpharmacological treatments for depression in cancer populations. MATERIALS AND

methodsThe Supportive Care Guidelines Group conducted a systematic review of the published literature through June 2005. Search sources includes MEDLINE, EMBASE, CINAHL, PsycInfo, and the Cochrane Library. Comparative studies of treatments for depression in cancer patients were selected for review by two group members based on predefined criteria. MAIN

resultsSeven trials of pharmacological agents and four of nonpharmacological interventions were identified. Two trials detected a significant reduction in depressive symptoms for mianserin compared with placebo, and one trial found alprazolam to be superior to progressive muscle relaxation. Four drug trials found no significant difference between groups on depression measures although posttreatment reduction of symptoms was observed for all groups in two trials comparing active treatments (fluoxetine vs desipramine and paroxetine vs amitriptyline). Of the four trials involving nonpharmacological therapies for the management of depression, two detected a benefit for treatment (a multicomponent nurse delivered intervention and an orientation program) over usual care.

conclusionThere is limited evidence for the effectiveness of pharmacological and psychosocial interventions in the treatment of cancer patients with depressive disorders, and no evidence for the superiority of one treatment modality over another. Based on evidence from the general population and other medically ill populations, combined approaches to the treatment of depression may be the most effective. Further research is necessary in cancer patients to determine the relative effectiveness of psychosocial, pharmacological, and combined treatments.

Indexed as

PsychotherapyAntidepressive AgentsClinical Trials as TopicDepressive DisorderHumansNeoplasmsTreatment OutcomeAntidepressive Agents

Identifiers

PMID17058100
OpenAlexW2053641615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.