ArticleOncogene2007
Transforming growth factor alpha promotes sequential conversion of mature astrocytes into neural progenitors and stem cells.
Article in Oncogene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 83 citations in OpenAlex.
- Deciphering the microenvironment of adult neurogenesis: a perspective from neurodegenerative diseases.Translational neurodegeneration · 2026Review
- miR-152-3p Overcomes Temozolomide Resistance in Glioblastoma by Targeting TGF-α and Enhancing Apoptosis.Oncology research · 2026Article
- Elevated expression and secretion of TGF-α contribute to Temozolomide resistance in human glioblastoma cells.Cancer cell international · 2025Article
- Activation of limbal epithelial proliferation is partly controlled by the ACE2-LCN2 pathway.iScience · 2024Article
- The Relationship of Astrocytes and Microglia with Different Stages of Ischemic Stroke.Current neuropharmacology · 2023Review
- Induction of Nanog in neural progenitor cells for adaptive regeneration of ischemic brain.Experimental & molecular medicine · 2022Article
- Article
- The Role of SVZ Stem Cells in Glioblastoma.Cancers · 2019Review
- Astrocytes: Role and Functions in Brain Pathologies.Frontiers in pharmacology · 2019Review
- Integrating the glioblastoma microenvironment into engineered experimental models.Future science OA · 2017Review
- Sonic hedgehog signalling mediates astrocyte crosstalk with neurons to confer neuroprotection.Journal of neurochemistry · 2017Article
- A role for ErbB signaling in the induction of reactive astrogliosis.Cell discovery · 2017Article
- Inflammation Promotes a Conversion of Astrocytes into Neural Progenitor Cells via NF-κB Activation.Molecular neurobiology · 2016Article
- Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke.Progress in neurobiology · 2016Review
- Therapeutical Strategies for Spinal Cord Injury and a Promising Autologous Astrocyte-Based Therapy Using Efficient Reprogramming Techniques.Molecular neurobiology · 2016Review
- Maintenance of glia in the optic lamina is mediated by EGFR signaling by photoreceptors in adult Drosophila.PLoS genetics · 2015Article
- Data in support of metabolic reprogramming in transformed mouse cortical astrocytes: A proteomic study.Data in brief · 2015Article
- Cancer stem cell immunology: key to understanding tumorigenesis and tumor immune escape?Frontiers in immunology · 2014Review
- Role of inflammation and its mediators in acute ischemic stroke.Journal of cardiovascular translational research · 2013Review
- The role of MMP-1 in breast cancer growth and metastasis to the brain in a xenograft model.BMC cancer · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An instability of the mature cell phenotype is thought to participate to the formation of gliomas, primary brain tumors deriving from astrocytes and/or neural stem cells. Transforming growth factor alpha (TGFalpha) is an erbB1 ligand overexpressed in the earliest stages of gliomas, and exerts trophic effects on gliomal cells and astrocytes. Here, we questioned whether prolonged TGFalpha exposure affects the stability of the normal mature astrocyte phenotype. We first developed astrocyte cultures devoid of residual neural stem cells or progenitors. We demonstrate that days of TGFalpha treatment result in the functional conversion of a population of mature astrocytes into radial glial cells, a population of neural progenitors. TGFalpha-generated radial glial cells support embryonic neurons migration, and give birth to cells of the neuronal lineage, expressing neuronal markers and the electrophysiological properties of neuroblasts. Lengthening TGFalpha treatment to months results in the delayed appearance of cells with neural stem cells properties: they form floating cellular spheres that are self-renewing, can be clonally derived from a single cell and differentiated into cells of the neuronal lineage. This study uncovers a novel population of mature astrocytes capable, in response to a single epigenetic factor, to regress progressively into a neural stem-like cell stage via an intermediate progenitor stage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.