Evidence map›Paper›PMID 17057556›Full record

Trial reportThe Clinical journal of pain

Behavioral responses to pain are heightened after clustered care in preterm infants born between 30 and 32 weeks gestational age.

Liisa Holsti, Ruth E Grunau, Michael F Whifield, Tim F Oberlander, Viveca Lindh

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Clinical journal of pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06173622 (Effects of Fetal Positioning on Pain and Physiological Parameters During Venipuncture in Preterm Neonates), which is not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
8.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06173622 nacompletednot on this map

Effects of Fetal Positioning on Pain and Physiological Parameters During Venipuncture in Preterm Neonates: A Randomized Controlled Trial

TypeinterventionalSponsorAnkara Yildirim Beyazıt UniversityRan2021 to 2022Enrolled60ConditionsPreterm Neonates, VenipunctureArmsFetal Positioning
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.

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  19. Developmental origins of the human hypothalamic-pituitary-adrenal axis.Expert review of endocrinology & metabolism · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Liisa HolstiCentre for Community Child Health Research, Child and Family Research Institute, Vancouver, Canada. lholsti@cw.bc.ca
Ruth E Grunau
Michael F Whifield
Tim F Oberlander
Viveca Lindh
University of British Columbia · CAChild and Family Research Institute · CAPolicyWise for Children & Families · CAUmeå University · SE

Funding

PAIN IN PRETERM INFANTS--DEVELOPMENT AND EFFECTSR01HD039783 · NICHD · UNIVERSITY OF BRITISH COLUMBIA · PI GRUNAU, RUTH E · 2001 to 2012
$1.8M
NICHD NIH HHS HD39783NICHD NIH HHS R01 HD039783
6 · The paper itself

Abstract

objectiveTo compare biobehavioral pain responses of preterm infants born at differing gestational ages (GAs) when pain was preceded by a rest period or by a series of routine nursing interventions.

methodsIn a randomized, within subjects, cross-over design, facial (Neonatal Facial Coding System), sleep/wake state and heart rate (HR) responses of 43 preterm infants [mean birth weight: 1303 g (range 590 g to 2345 g); mean GA at birth: 30 weeks (range 25 to 32)] were examined across 3 phases of blood collection (Baseline, Lance, and Recovery) under 2 conditions: pain after a 30-minute rest period versus pain after a series of routine nursing interventions (clustered care). Infant behavioral responses were coded from continuous bedside videotapes. HR was analyzed using custom physiologic signal processing software.

resultsInfants born at earlier GA (<30 wk) had equally intense facial responses during the Lance phase regardless of condition. However, later born infants (> or =30 wk GA) showed heightened facial responses indicative of sensitized responses during blood collection when it was preceded by clustered care (P=0.05). Moreover, later born infants had significantly lower facial (P=0.05) and HR (P=0.04) reactivity during Recovery when blood collection followed clustered care. DISCUSSION: Earlier born preterm infants showed heightened states of arousal and poor ability to modulate HR during Recovery when an invasive procedure was preceded by routine tactile nursing procedures. Alternatively, later born infants exhibited sensitized responses when clustered care preceded blood collection. Our findings support the importance of cue based individualized approaches to care.

Indexed as

Infant BehaviorInfant, PrematurePain MeasurementPremature BirthFacial ExpressionFemaleGestational AgeHumansInfant CareInfant, NewbornPainPregnancyTreatment Outcome

Identifiers

PMID17057556
PMCPMC1851898
OpenAlexW1997434265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.