ArticleJournal of biomedicine & biotechnology2006
Delivery systems for the direct application of siRNAs to induce RNA interference (RNAi) in vivo.
Article in Journal of biomedicine & biotechnology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 132 citations in OpenAlex.
- Recent Update on siRNA Therapeutics.International journal of molecular sciences · 2025Review
- Biofunctionalized Decellularized Tissue-Engineered Heart Valve with Mesoporous Silica Nanoparticles for Controlled Release of VEGF and RunX2-siRNA against Calcification.Bioengineering (Basel, Switzerland) · 2023Article
- Research Advances of Injectable Functional Hydrogel Materials in the Treatment of Myocardial Infarction.Gels (Basel, Switzerland) · 2022Review
- Article
- Complex fibroblast response to glucocorticoids may underlie variability of clinical efficacy in the vocal folds.Scientific reports · 2020Article
- Skin Delivery of siRNA Using Sponge Spicules in Combination with Cationic Flexible Liposomes.Molecular therapy. Nucleic acids · 2020Article
- Osteoblasts mineralization and collagen matrix are conserved upon specificMatrix biology plus · 2020Article
- Silencing of spinal Trpv1 attenuates neuropathic pain in rats by inhibiting CAMKII expression and ERK2 phosphorylation.Scientific reports · 2019Article
- Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach.International journal of nanomedicine · 2019Review
- AKT2 siRNA delivery with amphiphilic-based polymeric micelles show efficacy against cancer stem cells.Drug delivery · 2018Article
- Activation of cyclin D1 affects mitochondrial mass following traumatic brain injury.Neurobiology of disease · 2018Article
- MicroRNAs-103/107 Regulate Autophagy in the Epidermis.The Journal of investigative dermatology · 2018Article
- Role of MicroRNAs in Renal Parenchymal Diseases-A New Dimension.International journal of molecular sciences · 2018Review
- Nanoparticle delivery of RNA-based therapeutics to alter the vocal fold tissue response to injury.The Laryngoscope · 2018Article
- hTERT gene knockdown enhances response to radio- and chemotherapy in head and neck cancer cell lines through a DNA damage pathway modification.Scientific reports · 2018Article
- Oral delivery of curcuminJournal of materials chemistry. B · 2017Article
- Preliminary study of a novel transfection modality for in vivo siRNA delivery to vocal fold fibroblasts.The Laryngoscope · 2017Article
- Sustained delivery of siRNA/PEI complex from in situ forming hydrogels potently inhibits the proliferation of gastric cancer.Journal of experimental & clinical cancer research : CR · 2016Article
- Topical delivery of siRNA into skin using SPACE-peptide carriers.Journal of controlled release : official journal of the Controlled Release Society · 2014Article
- Vertically integrated translational studies of PDX1 as a therapeutic target for pancreatic cancer via a novel bifunctional RNAi platform.Cancer gene therapy · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA interference (RNAi) is a powerful method for specific gene silencing which may also lead to promising novel therapeutic strategies. It is mediated through small interfering RNAs (siRNAs) which sequence-specifically trigger the cleavage and subsequent degradation of their target mRNA. One critical factor is the ability to deliver intact siRNAs into target cells/organs in vivo. This review highlights the mechanism of RNAi and the guidelines for the design of optimal siRNAs. It gives an overview of studies based on the systemic or local application of naked siRNAs or the use of various nonviral siRNA delivery systems. One promising avenue is the the complexation of siRNAs with the polyethylenimine (PEI), which efficiently stabilizes siRNAs and, upon systemic administration, leads to the delivery of the intact siRNAs into different organs. The antitumorigenic effects of PEI/siRNA-mediated in vivo gene-targeting of tumor-relevant proteins like in mouse tumor xenograft models are described.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.