ArticleGenetics2006
A population genetics pedigree perspective on the transmission of Helicobacter pylori.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Analysis of 1321 Eubacterium rectale genomes from metagenomes uncovers complex phylogeographic population structure and subspecies functional adaptations.Genome biology · 2020Article
- From Evolutionary Advantage to Disease Agents: Forensic Reevaluation of Host-Microbe Interactions and Pathogenicity.Microbiology spectrum · 2017Review
- Elevated levels of adaption in Helicobacter pylori genomes from Japan; a link to higher incidences of gastric cancer?Evolution, medicine, and public health · 2015Article
- Population genetic structure and isolation by distance of Helicobacter pylori in Senegal and Madagascar.PloS one · 2014Article
- Genomic evolution and transmission of Helicobacter pylori in two South African families.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Recent acquisition of Helicobacter pylori by Baka pygmies.PLoS genetics · 2013Article
- Relatedness of Helicobacter pylori populations to gastric carcinogenesis.World journal of gastroenterology · 2012Review
- First degree relatives and familial aggregation of gastric cancer: who to choose for control in case-control studies?Familial cancer · 2012Article
- Age of the association between Helicobacter pylori and man.PLoS pathogens · 2012Article
- Helicobacter pylori in apparently healthy children aged 0-12 years in urban Kampala, Uganda: a community-based cross sectional survey.BMC gastroenterology · 2010Article
- DNA-level diversity and relatedness of Helicobacter pylori strains in shantytown families in Peru and transmission in a developing-country setting.Journal of clinical microbiology · 2008Article
- Horizontal versus familial transmission of Helicobacter pylori.PLoS pathogens · 2008Article
- Genetic analysis of Helicobacter pylori strain populations colonizing the stomach at different times postinfection.Journal of bacteriology · 2007Article
- Absence of Helicobacter pylori within the oral cavities of members of a healthy South African community.Journal of clinical microbiology · 2006Article
- Comparison of amoxicillin and metronidazole effect on three-drug regimen for the treatment ofJournal of advanced pharmaceutical technology & researchArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inference of transmission pathways for medicinally important bacteria is important to our understanding of pathogens. Here we report analyses of transmission in Helicobacter pylori, a major carcinogen. Our study is novel in that the focal community comprises detailed family pedigrees and has a high prevalence of H. pylori. To infer transmission, we performed high-resolution analyses of nucleotide sequences for three genes and accounted for the occurrence of mutation and recombination through the use of simulation modeling. Our results demonstrate that transmission has a strong nonfamilial component potentially the result of a large proportion of infections derived from the community. These results are interesting from both a medical and an evolutionary standpoint. First, efficient control measures and beliefs about the sources of H. pylori infection should be reevaluated. Evolutionarily, our results contradict the hypothesis of strict vertical transmission, presented as an explanation for the strong correlation between human population history and H. pylori diversity. Thus the paradox of persistent phylogenetic structure, despite a permissive mode of transmission and high recombination rates, must be solved elsewhere. Here we consider the potential for recombination events to maintain genetic structure in light of horizontal transmission.
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