ArticleGenetics2006
Unexpected high polymorphism at the FABP4 gene unveils a complex history for pig populations.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Population structure and domestication history of the Javan banteng.Current biology : CB · 2026Article
- Expression analysis of candidate genes for fatty acid composition in adipose tissue and identification of regulatory regions.Scientific reports · 2018Article
- Contacts in the last 90,000 years over the Strait of Gibraltar evidenced by genetic analysis of wild boar (Sus scrofa).PloS one · 2017Article
- Haplotypic diversity of porcine LEP and LEPR genes involved in growth and fatness regulation.Journal of applied genetics · 2015Article
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- Allelic variation in ovine fatty acid-binding protein (FABP4) gene.Molecular biology reports · 2012Article
- A comparison of brain gene expression levels in domesticated and wild animals.PLoS genetics · 2012Article
- Nucleotide variability and linkage disequilibrium patterns in the porcine MUC4 gene.BMC genetics · 2012Article
- Deciphering the genetic basis of animal domestication.Proceedings. Biological sciences · 2011Review
- Partial short-read sequencing of a highly inbred Iberian pig and genomics inference thereof.Heredity · 2011Article
- The genetic structure of domestic rabbits.Molecular biology and evolution · 2011Article
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- Optimal neutrality tests based on the frequency spectrum.Genetics · 2010Article
- A single nucleotide polymorphism in the porcine cathepsin K (CTSK) gene is associated with back fat thickness and production traits in Italian Duroc pigs.Molecular biology reports · 2010Article
- Selection in the making: a worldwide survey of haplotypic diversity around a causative mutation in porcine IGF2.Genetics · 2008Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatty acid bing protein 4 (FABP4) plays a key role in fat regulation in mammals and is a strong positional candidate gene for the FAT1 quantitative trait locus located on porcine chromosome 4. DNA resequencing of the FABP4 gene region in 23 pigs from 10 breeds and wild boar revealed 134 variants in 6.4 kb, representing a silent nucleotide diversity of piS=0.01, much higher than reported so far in animal domestic species. Moreover, this diversity was highly structured. Also strikingly, the FABP4 phylogenetic tree did not show any geographical or breed origin clustering, with distant breeds sharing similar haplotypes and some of the most heterozygous samples pertaining to highly inbred animals like Iberian Guadyerbas (inbreeding coefficient approximately 0.3) or British Tamworth. In contrast, the cytochrome b (mtDNA) phylogenetic tree was coherent with geographical origin. The estimated age of the most recent common ancestor for the most divergent Iberian or Tamworth haplotypes was much older than domestication. An additional panel of 100 pigs from 8 different breeds and wild boar from Spain, Tunisia, Sardinia, and Japan was genotyped for seven selected single nucleotide polymorphisms and shows that high variability at the porcine FABP4 is the rule rather than the exception. Pig populations, even highly inbred, can maintain high levels of variability for surprisingly long periods of time.
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