ArticleGenetics2007
Identification of selective sweeps using a dynamically adjusted number of linked microsatellites.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A Likelihood Approach for Uncovering Selective Sweep Signatures from Haplotype Data.Molecular biology and evolution · 2020Article
- Detecting Recent Positive Selection with a Single Locus Test Bipartitioning the Coalescent Tree.Genetics · 2018Article
- Molecular Population Genetics.Genetics · 2017Review
- Coalescent tree imbalance and a simple test for selective sweeps based on microsatellite variation.PLoS computational biology · 2013Article
- A microsatellite-based analysis for the detection of selection on BTA1 and BTA20 in northern Eurasian cattle (Bos taurus) populations.Genetics, selection, evolution : GSE · 2010Article
- Article
- Simulation of DNA sequence evolution under models of recent directional selection.Briefings in bioinformatics · 2009Article
- Identification of selective sweeps in closely related populations of the house mouse based on microsatellite scans.Genetics · 2008Article
- Signatures of selection in natural populations adapted to chronic pollution.BMC evolutionary biology · 2008Article
- Article
- Evolutionary dynamics of molecular markers during local adaptation: a case study in Drosophila subobscura.BMC evolutionary biology · 2008Article
- Hitchhiking mapping reveals a candidate genomic region for natural selection in three-spined stickleback chromosome VIII.Genetics · 2008Article
- Patterns of genetic diversity and candidate genes for ecological divergence in a homoploid hybrid sunflower, Helianthus anomalus.Molecular ecology · 2007Article
- Selective sweeps in the homoploid hybrid species Helianthus deserticola: evolution in concert across populations and across origins.Molecular ecology · 2007Article
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4 authors.
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Abstract
There is currently large interest in distinguishing the signatures of genetic variation produced by demographic events from those produced by natural selection. We propose a simple multilocus statistical test to identify candidate sites of selective sweeps with high power. The test is based on the variability profile measured in an array of linked microsatellites. We also show that the analysis of flanking markers drastically reduces the number of false positives among the candidates that are identified in a genomewide survey of unlinked loci and find that this property is maintained in many population-bottleneck scenarios. However, for a certain range of intermediately severe population bottlenecks we find genomic signatures that are very similar to those produced by a selective sweep. While in these worst-case scenarios the power of the proposed test remains high, the false-positive rate reaches values close to 50%. Hence, selective sweeps may be hard to identify even if multiple linked loci are analyzed. Nevertheless, the integration of information from multiple linked loci always leads to a considerable reduction of the false-positive rate compared to a genome scan of unlinked loci. We discuss the application of this test to experimental data from Drosophila melanogaster.
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