ArticleEmergency medicine journal : EMJ2006
Impairment of coagulation by commonly used resuscitation fluids in human volunteers.
Article in Emergency medicine journal : EMJ, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Introduction of a standardised protocol, including systematic use of tranexamic acid, for management of severe adult trauma patients in a low-resource setting: the MSF experience from Port-au-Prince, Haiti.BMC emergency medicine · 2019Trial
- Internal fibrinolysis of fibrin clots is driven by pore expansion.Scientific reports · 2024Article
- Association between Functional Parameters of Coagulation and Conventional Coagulation Tests in the Setting of Fluid Resuscitation with Balanced Crystalloid or Gelatine: A Secondary Analysis of an In Vivo Prospective Randomized Crossover Study.Journal of clinical medicine · 2022Article
- Chinese expert consensus on diagnosis and treatment of coagulation dysfunction in COVID-19.Military Medical Research · 2020Article
- Early diuretic use and mortality in critically ill patients with vasopressor support: a propensity score-matching analysis.Critical care (London, England) · 2019Article
- Time-related association between fluid balance and mortality in sepsis patients: interaction between fluid balance and haemodynamics.Scientific reports · 2018Article
- The pathophysiology, diagnosis and treatment of the acute coagulopathy of trauma and shock: a literature review.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2015Review
- Conservative fluid therapy in septic shock: an example of targeted therapeutic minimization.Critical care (London, England) · 2014Review
- [Trauma-induced coagulopathy].Der Unfallchirurg · 2014Article
- Fluid balance and cardiac function in septic shock as predictors of hospital mortality.Critical care (London, England) · 2013Article
- Determinants of hospital mortality among patients with sepsis or septic shock receiving appropriate antibiotic treatment.Current infectious disease reports · 2013Article
- Cardiovascular management of septic shock in 2012.Current infectious disease reports · 2012Article
- The treatment of traumatic shock: recent advances and unresolved questions.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2011Article
- Acute coagulopathy in isolated blunt traumatic brain injury.Neurocritical care · 2010Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study compared the effects of two commonly used resuscitation fluids on whole blood coagulation.
methods1000 ml of two resuscitation fluids each (saline and Gelofusine) were given to eight volunteers in a crossover design with a 2-week washout period. The effect on whole blood coagulation was assessed using the Sonoclot analyzer, a conventional coagulation screen and coagulation markers.
resultsNo significant effect was found on whole blood coagulation by giving saline (time to peak clot increased by a mean of 106 s; (95% confidence interval (CI) -140 to 354), whereas Gelofusine delayed the time to peak by a mean of 845 s (95% CI 435 to 1255). By contrast, there was no change in the conventional coagulation screen with either fluid.
conclusionIt was concluded that some resuscitation fluids have an effect on clot formation that is not shown by the conventional coagulation screen, but is disclosed only if the whole coagulation process is studied.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.