ArticleProceedings of the National Academy of Sciences of the United States of America1991
Heritable retroviral transgenes are highly expressed in chickens.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 36 citations in OpenAlex.
- Efficient production of transgenic chickens based on piggyBac.Transgenic research · 2013Article
- Retroviral insertional activation in a herpesvirus: transcriptional activation of US genes by an integrated long terminal repeat in a Marek's disease virus clone.Journal of virology · 1996Article
- Heart targeting of retroviral expression in avian embryos: a species-independent phenomenon.Roux's archives of developmental biology : the official organ of the EDBO · 1995Article
- Transgenesis in chickens.Transgenic research · 1993Review
- Replication-competent retroviral vectors encoding alkaline phosphatase reveal spatial restriction of viral gene expression/transduction in the chick embryo.Molecular and cellular biology · 1993Article
- Retroviral infection coupled with tissue transplantation limits gene transfer in the chicken embryo.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Appropriate in vivo expression of a muscle-specific promoter by using avian retroviral vectors for gene transfer [corrected].Journal of virology · 1992Article
- Production of transgenic birds.Experientia · 1991Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This report describes expression of heritable reticuloendotheliosis virus (REV) vector ME111 in 20 independent lines of transgenic chickens. The results are strikingly different from studies of Moloney virus in transgenic mice, where restricted expression of inherited proviruses has led to their use primarily as insertional mutagens rather than general agents for gene transfer. In contrast, the REV ME111 provirus is actively transcribed in a variety of tissues from transgenic chickens, is expressed from transcriptional control elements present in the long terminal repeat of the provirus, and codes for active neomycin phosphotransferase II. The REV vector system as applied to the chicken represents a departure from the long-established paradigm of retroviral transgenes in mice and provides a new approach to the study of avian biology.
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Registered trials
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