ArticleJournal of bacteriology2007
Chlamydial type III secretion system is encoded on ten operons preceded by sigma 70-like promoter elements.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression ineLife · 2025Article
- The T3SS structural and effector genes ofFrontiers in cellular and infection microbiology · 2025Article
- Insights into Chlamydia Development and Host Cells Response.Microorganisms · 2024Review
- Type III Secretion inMicrobiology and molecular biology reviews : MMBR · 2023Review
- Diversity of σJournal of bacteriology · 2023Article
- A Same-Genus Screening Approach Reveals Novel Effectors and New Possibilities for InvestigatingJournal of bacteriology · 2021Article
- Application of aJournal of bacteriology · 2021Article
- Robust Heat Shock Response inFrontiers in microbiology · 2021Article
- Article
- Context-Dependent Action of Scc4 Reinforces Control of the Type III Secretion System.Journal of bacteriology · 2020Article
- Article
- Floxed-Cassette Allelic Exchange Mutagenesis Enables Markerless Gene Deletion in Chlamydia trachomatis and Can Reverse Cassette-Induced Polar Effects.Journal of bacteriology · 2018Article
- Population-based analysis of ocular Chlamydia trachomatis in trachoma-endemic West African communities identifies genomic markers of disease severity.Genome medicine · 2018Article
- Emancipating Chlamydia: Advances in the Genetic Manipulation of a Recalcitrant Intracellular Pathogen.Microbiology and molecular biology reviews : MMBR · 2016Review
- A working model for the type III secretion mechanism in Chlamydia.Microbes and infection · 2016Review
- Article
- Quantitative Proteomics of the Infectious and Replicative Forms of Chlamydia trachomatis.PloS one · 2016Article
- Multipart Chaperone-Effector Recognition in the Type III Secretion System of Chlamydia trachomatis.The Journal of biological chemistry · 2015Article
- Hypothetical protein CT398 (CdsZ) interacts with σ(54) (RpoN)-holoenzyme and the type III secretion export apparatus in Chlamydia trachomatis.Protein science : a publication of the Protein Society · 2015Article
- Mutational Analysis of the Chlamydia muridarum Plasticity Zone.Infection and immunity · 2015Article
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Authors and funding
2 authors.
Funding
Abstract
Many gram-negative bacterial pathogens employ type III secretion systems for infectious processes. Chlamydiae are obligate intracellular bacteria that encode a conserved type III secretion system that is likely requisite for growth. Typically, genes encoding type III secretion systems are located in a single locus; however, for chlamydiae these genes are scattered throughout the genome. Little is known regarding the gene regulatory mechanisms for this essential virulence determinant. To facilitate identification of cis-acting transcriptional regulatory elements, the operon structure was determined. This analysis revealed 10 operons that contained 37 genes associated with the type III secretion system. Linkage within these operons suggests a role in type III secretion for each of these genes, including 13 genes encoding proteins with unknown function. The transcriptional start site for each operon was determined. In conjunction with promoter activity assays, this analysis revealed that the type III secretion system operons encode sigma(70)-like promoter elements. Transcriptional initiation by a sigma factor responsible for constitutive gene expression indicates that undefined activators or repressors regulate developmental stage-specific expression of chlamydial type III secretion system genes.
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