ArticleBiophysical journal2007
Competitive displacement of DNA during surface hybridization.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Hamming Distance as a Concept in DNA Molecular Recognition.ACS omega · 2017Article
- Kinetic mechanisms in morpholino-DNA surface hybridization.Journal of the American Chemical Society · 2011Article
- Rapid genotyping of human papillomavirus by post-PCR array-based hybridization techniques.Journal of clinical microbiology · 2011Article
- Salt concentration effects on equilibrium melting curves from DNA microarrays.Biophysical journal · 2010Article
- Real-time DNA microarray analysis.Nucleic acids research · 2009Article
- Real-time DNA microarrays: reality check.Biochemical Society transactions · 2009Review
- Aptamer selection express: a novel method for rapid single-step selection and sensing of aptamers.Journal of biomolecular techniques : JBT · 2008Article
- A study of the relationships between oligonucleotide properties and hybridization signal intensities from NimbleGen microarray datasets.Nucleic acids research · 2008Article
- Specificity of DNA microarray hybridization: characterization, effectors and approaches for data correction.Nucleic acids research · 2008Review
- Kinetics of multiplex hybridization: mechanisms and implications.Biophysical journal · 2008Article
- Multiplex SNP discrimination.Biophysical journal · 2007Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using real-time dual-color fluorescence detection, we have experimentally tracked individual target species during competitive DNA surface hybridization in a two-component sample. Our experimental results demonstrate displacement of the lower affinity species by the higher affinity species and corroborate recent theoretical models describing competitive DNA surface hybridization. Competition at probe sites complementary to one of the two DNA species was monitored in separate experiments for two different target pairs. Each pair differs in sequence by a single nucleotide polymorphism, and one pair includes a folding target. We propose a mechanistic interpretation of the differences between hybridization curves of targets in multi-component and single-component experiments.
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Registered trials
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