ArticleBiophysical journal2007
Effect of surfactant protein A on the physical properties and surface activity of KL4-surfactant.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Surfactant therapy in neonatal care: advances, challenges, and practical considerations.European journal of pediatrics · 2026Review
- On the synergy between myelin proteins P0, MBP, and P2 in peripheral nerve major dense line formation.The FEBS journal · 2025Article
- Lung surfactant as a biophysical assay for inhalation toxicology.Current research in toxicology · 2023Review
- A recipe for a good clinical pulmonary surfactant.Biomedical journal · 2022Review
- Lipid-Protein and Protein-Protein Interactions in the Pulmonary Surfactant System and Their Role in Lung Homeostasis.International journal of molecular sciences · 2020Review
- Lung Surfactant Lipids Provide Immune Protection AgainstFrontiers in immunology · 2019Article
- Folding and Intramembraneous BRICHOS Binding of the Prosurfactant Protein C Transmembrane Segment.The Journal of biological chemistry · 2015Article
- The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles.PloS one · 2012Article
- Bacterial lipopolysaccharide promotes destabilization of lung surfactant-like films.Biophysical journal · 2011Article
- A theoretical study of diffusional transport over the alveolar surfactant layer.Journal of the Royal Society, Interface · 2010Article
- SP-A permeabilizes lipopolysaccharide membranes by forming protein aggregates that extract lipids from the membrane.Biophysical journal · 2008Article
- Structural and functional differences among human surfactant proteins SP-A1, SP-A2 and co-expressed SP-A1/SP-A2: role of supratrimeric oligomerization.The Biochemical journal · 2007Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SP-A, the major protein component of pulmonary surfactant, is absent in exogenous surfactants currently used in clinical practice. However, it is thought that therapeutic properties of natural surfactants improve after enrichment with SP-A. The objective of this study was to determine SP-A effects on physical properties and surface activity of a new synthetic lung surfactant based on a cationic and hydrophobic 21-residue peptide KLLLLKLLLLKLLLLKLLLLK, KL(4). We have analyzed the interaction of SP-A with liposomes consisting of DPPC/POPG/PA (28:9:5.6, w/w/w) with and without 0.57 mol % KL(4) peptide. We found that SP-A had a concentration-dependent effect on the surface activity of KL(4)-DPPC/POPG/PA membranes but not on that of an animal-derived LES. The surface activity of KL(4)-surfactant significantly improved after enrichment with 2.5-5 wt % SP-A. However, it worsened at SP-A concentrations > or =10 wt %. This was due to the fluidizing effect of supraphysiological SP-A concentrations on KL(4)-DPPC/POPG/PA membranes as determined by fluorescence anisotropy measurements, calorimetric studies, and confocal fluorescence microscopy of GUVs. High SP-A concentrations caused disappearance of the solid/fluid phase coexistence of KL(4)-surfactant, suggesting that phase coexistence might be important for the surface adsorption process.
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