ArticleCerebral cortex (New York, N.Y. : 1991)2007
Mapping cortical thickness in children with 22q11.2 deletions.
Article in Cerebral cortex (New York, N.Y. : 1991), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Magnitude and heterogeneity of brain structural abnormalities in 22q11.2 deletion syndrome: a meta-analysis.Molecular psychiatry · 2020Pooled it
- A resting state fMRI analysis pipeline for pooling inference across diverse cohorts: an ENIGMA rs-fMRI protocol.Brain imaging and behavior · 2019Pooled it
- Psychiatric comorbidity in DiGeorge association: Suicidal ideation and bipolar disorder.Journal of mood and anxiety disorders · 2026Article
- Robust and replicable functional brain signatures of 22q11.2 deletion syndrome and associated psychosis: a deep neural network-based multi-cohort study.Molecular psychiatry · 2024Article
- Review
- Article
- Copy Number Variations and Schizophrenia.Molecular neurobiology · 2023Review
- Involvement of an Aberrant Vascular System in Neurodevelopmental, Neuropsychiatric, and Neuro-Degenerative Diseases.Life (Basel, Switzerland) · 2023Review
- A Comprehensive Analysis of Cerebellar Volumes in the 22q11.2 Deletion Syndrome.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Heterotopia in Individuals with 22q11.2 Deletion Syndrome.AJNR. American journal of neuroradiology · 2021Article
- Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size.Molecular psychiatry · 2020Article
- Tissue Engineering and Biomaterial Strategies to Elicit Endogenous Neuronal Replacement in the Brain.Frontiers in neurology · 2020Review
- Neurobiological perspective of 22q11.2 deletion syndrome.The lancet. Psychiatry · 2019Review
- Abnormal development of early auditory processing in 22q11.2 Deletion Syndrome.Translational psychiatry · 2019Article
- Genetic risk for schizophrenia and developmental delay is associated with shape and microstructure of midline white-matter structures.Translational psychiatry · 2019Article
- Periventricular nodular heterotopia in 22q11.2 deletion and frontal lobe migration.Annals of clinical and translational neurology · 2018Article
- Genotype-phenotype association study via new multi-task learning model.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2018Article
- White matter microstructural deficits in 22q11.2 deletion syndrome.Psychiatry research. Neuroimaging · 2017Article
- Autism spectrum disorder: neuropathology and animal models.Acta neuropathologica · 2017Review
- Mapping 22q11.2 Gene Dosage Effects on Brain Morphometry.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
The 22q11.2 deletion syndrome (velocardiofacial/DiGeorge syndrome, 22q11.2DS) involves cardiac and craniofacial anomalies, marked deficits in visuospatial cognition, and elevated rates of psychosis. Although the mechanism is unknown, characteristic brain alterations may predispose to development of psychosis and cognitive deficits in 22q11DS. We applied cortical pattern matching and new methods for measuring cortical thickness in millimeters to structural magnetic resonance images of 21 children with confirmed 22q11.2 deletions and 13 demographically matched healthy comparison subjects. Thickness was mapped at 65 536 homologous points, based on 3-dimensional distance from the cortical gray-white matter interface to the external gray-cerebrospinal fluid boundary. A pattern of regionally specific cortical thinning was observed in superior parietal cortices and right parietooccipital cortex, regions critical for visuospatial processing, and bilaterally in the most inferior portion of the inferior frontal gyrus (pars orbitalis), a key area for language development. Several of the 30 genes encoded in the deleted segment are highly expressed in the developing brain and known to affect early neuronal migration. These brain maps reveal how haploinsufficiency for such genes can affect cortical development and suggest a possible underlying pathophysiology of the neurobehavioral phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.