Trial reportJournal of neurology, neurosurgery, and psychiatry2007
Functional and magnetic resonance imaging correlates of corpus callosum in normal pressure hydrocephalus before and after shunting.
Trial report in Journal of neurology, neurosurgery, and psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06857136 (The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus (Third Edition): Endorsed by the Japanese Society of Normal Pressure Hydrocephalus.Neurologia medico-chirurgica · 2021Guideline
- The effect of shunt surgery on neuropsychological performance in normal pressure hydrocephalus: a systematic review and meta-analysis.Journal of neurology · 2016Pooled it
- Analyzing the relationship between specific brain structural changes and the diffusion tensor image analysis along the perivascular space index in idiopathic normal pressure hydrocephalus.Journal of neurology · 2024Article
- Intravoxel incoherent motion magnetic resonance imaging in the assessment of brain microstructure and perfusion in idiopathic normal-pressure hydrocephalus.Neuroradiology · 2024Article
- Clinical Features of Idiopathic Normal Pressure Hydrocephalus: Critical Review of Objective Findings.Movement disorders clinical practice · 2023Review
- Radiological biomarkers of idiopathic normal pressure hydrocephalus: new approaches for detecting concomitant Alzheimer's disease and predicting prognosis.Psychoradiology · 2022Review
- Cognitive Impairment in Idiopathic Normal Pressure Hydrocephalus.Neuroscience bulletin · 2022Review
- Relationship between cognitive profile and neuroradiographic parameters in patients with idiopathic normal pressure hydrocephalus.Current journal of neurology · 2022Article
- Pathophysiological Mechanisms Underlying Idiopathic Normal Pressure Hydrocephalus: A Review of Recent Insights.Frontiers in aging neuroscience · 2022Review
- The topology of ventricle surfaces and its application in the analysis of hydrocephalic ventricles: a proof-of-concept study.Neuroradiology · 2021Article
- The role of diffusion tensor imaging in idiopathic normal pressure hydrocephalus: A literature review.The neuroradiology journal · 2021Review
- Diffusion tensor imaging in idiopathic normal pressure hydrocephalus: clinical and CSF flowmetry correlations.The neuroradiology journal · 2020Article
- Association between the Onset of Idiopathic Normal Pressure Hydrocephalus Symptoms and Reduced Default Mode Network Connectivity.Dementia and geriatric cognitive disorders · 2020Article
- Article
- Asymmetric and Upper Body Parkinsonism in Patients with Idiopathic Normal-Pressure Hydrocephalus.Journal of clinical neurology (Seoul, Korea) · 2016Article
- DTI-MRI biomarkers in the search for normal pressure hydrocephalus aetiology: a review.Neurosurgical review · 2015Review
- Diffusion tensor imaging in elderly patients with idiopathic normal pressure hydrocephalus or Parkinson's disease: diagnosis of gait abnormalities.Fluids and barriers of the CNS · 2012Article
- [Hydrocephalus and intracranial hypotension].Der Radiologe · 2012Review
- Different patterns of fornix damage in idiopathic normal pressure hydrocephalus and Alzheimer disease.AJNR. American journal of neuroradiology · 2012Article
- The differential diagnosis and treatment of normal-pressure hydrocephalus.Deutsches Arzteblatt international · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNormal pressure hydrocephalus (NPH) is associated with corpus callosum abnormalities.
objectivesTo study the clinical and neuropsychological effect of callosal thinning in 18 patients with idiopathic NPH and to investigate the postsurgical callosal changes in 14 patients.
methodsGlobal corpus callosum size and seven callosal subdivisions were measured. Neuropsychological assessment included an extensive battery assessing memory, psychomotor speed, visuospatial and frontal lobe functioning.
resultsAfter surgery, patients showed improvements in memory, visuospatial and frontal lobe functions, and psychomotor speed. Two frontal corpus callosum areas, the genu and the rostral body, were the regions most related to the clinical and neuropsychological dysfunction. After surgery, total corpus callosum and four of the seven subdivisions presented a significant increase in size, which was related to poorer neuropsychological and clinical outcome.
conclusionThe postsurgical corpus callosum increase might be the result of decompression, re-expansion and increase of interstitial fluid, although it may also be caused by differences in shape due to cerebral reorganisation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.