Trial reportBiological psychiatry2006
Lithium treatment effects on Myo-inositol in adolescents with bipolar depression.
Trial report in Biological psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Lithium effects in the frontolimbic circuitry: a systematic review of neuroimaging findings in bipolar disorder.Translational psychiatry · 2026Pooled it
- A Randomized, Double-Blind, Controlled Trial of Lithium Versus Quetiapine for the Treatment of Acute Mania in Youth with Early Course Bipolar Disorder.Journal of child and adolescent psychopharmacology · 2021Trial
- Neurometabolite effects of response to quetiapine and placebo in adolescents with bipolar depression.Journal of child and adolescent psychopharmacology · 2012Trial
- Randomized double-blind placebo-controlled trial of lithium in youths with severe mood dysregulation.Journal of child and adolescent psychopharmacology · 2009Trial
- Brain lithium, N-acetyl aspartate and myo-inositol levels in older adults with bipolar disorder treated with lithium: a lithium-7 and proton magnetic resonance spectroscopy study.Bipolar disorders · 2008Trial
- Neurobiology and Applications of Inositol in Psychiatry: A Narrative Review.Current issues in molecular biology · 2023Review
- Research Status in Clinical Practice Regarding Pediatric and Adolescent Bipolar Disorders.Frontiers in psychiatry · 2022Review
- Osmoregulatory inositol transporter SMIT1 modulates electrical activity by adjusting PI(4,5)P2 levels.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Molecular actions and clinical pharmacogenetics of lithium therapy.Pharmacology, biochemistry, and behavior · 2014Review
- A review of MR spectroscopy studies of pediatric bipolar disorder.AJNR. American journal of neuroradiology · 2014Review
- N-acetyl aspartate levels in adolescents with bipolar and/or cannabis use disorders.Journal of dual diagnosis · 2014Article
- Prospective neurochemical characterization of child offspring of parents with bipolar disorder.Psychiatry research · 2013Article
- The neural effects of psychotropic medications in children and adolescents.Child and adolescent psychiatric clinics of North America · 2012Review
- Frontal lobe bioenergetic metabolism in depressed adolescents with bipolar disorder: a phosphorus-31 magnetic resonance spectroscopy study.Bipolar disorders · 2012Article
- Antidepressants and psychostimulants in pediatric populations: is there an association with mania?Paediatric drugs · 2011Review
- Review: magnetic resonance spectroscopy studies of pediatric major depressive disorder.Depression research and treatment · 2011Article
- Brain glutamatergic characteristics of pediatric offspring of parents with bipolar disorder.Psychiatry research · 2010Article
- Neurochemical alterations in adolescent bipolar depression: a proton magnetic resonance spectroscopy pilot study of the prefrontal cortex.Journal of child and adolescent psychopharmacology · 2008Article
- Biologic basis of bipolar disorder in children and adolescents.Current psychiatry reports · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe neurochemical effects of lithium in adolescents with bipolar disorder largely are unknown. This study used proton magnetic resonance spectroscopy (1H MRS) to identify the in vivo effects of lithium on myo-inositol (mI) concentrations in adolescent bipolar depression.
methodsTwenty-eight adolescents (12-18 years old) with bipolar I disorder, current episode depressed, received open-label lithium 30 mg/kg, adjusted to achieve serum levels of 1.0-1.2 mEq/L. The mI concentrations in the medial as well as the left and right lateral prefrontal cortices were measured at baseline, day 7, and day 42 of treatment. Changes in mI concentrations over time were analyzed.
resultsSignificant main effects of time were observed for mI concentrations in the medial (p = .03) and right lateral (p = .05) prefrontal cortices. Baseline concentrations of mI were not significantly different from day 7 or day 42 concentrations. However, mI concentrations on day 42 were significantly higher than those on day 7 (p = .02) in both regions.
conclusionsThis study demonstrates that prefrontal mI concentrations do not significantly change from baseline after acute and chronic lithium treatment in adolescents with bipolar depression. Further investigation of the effect of lithium on mI is warranted to better understand possible mechanisms by which lithium exerts antidepressant activity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.