ArticleThrombosis research2007
Involvement of Src kinases and PLCgamma2 in clot retraction.
Article in Thrombosis research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 71 citations in OpenAlex.
- Unresolved mechanisms: a hypothesized spatial regulation of myosin light chain phosphorylation within the walls of resistance arteries.Frontiers in physiology · 2026Article
- Platelet spreading and clot retraction are regulated by 2 distinct αThe Journal of pharmacology and experimental therapeutics · 2025Article
- Filamin A regulates platelet shape change and contractile force generation via phosphorylation of the myosin light chain.The Biochemical journal · 2024Article
- Single-pericyte nanomechanics measured by contraction cytometry.APL bioengineering · 2024Article
- Comparative antiplatelet and antithrombotic effects of red ginseng and fermented red ginseng extracts.Journal of ginseng research · 2022Article
- 1,8-Cineole Affects Agonists-Induced Platelet Activation, Thrombus Formation and Haemostasis.Cells · 2021Article
- Clot Retraction: Cellular Mechanisms and Inhibitors, Measuring Methods, and Clinical Implications.Biomedicines · 2021Review
- Article
- Matrine Impairs Platelet Function and Thrombosis and Inhibits ROS Production.Frontiers in pharmacology · 2021Article
- Extract of SeaweedFrontiers in pharmacology · 2021Article
- Antiplatelet and Antithrombotic Effects ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Molecular Drivers of Platelet Activation: Unraveling Novel Targets for Anti-Thrombotic and Anti-Thrombo-Inflammatory Therapy.International journal of molecular sciences · 2020Review
- p47phox deficiency impairs platelet function and protects mice against arterial and venous thrombosis.Redox biology · 2020Article
- Salidroside inhibits platelet function and thrombus formation through AKT/GSK3β signaling pathway.Aging · 2020Article
- Feeling the Force: Measurements of Platelet Contraction and Their Diagnostic Implications.Seminars in thrombosis and hemostasis · 2019Article
- Platycodin D inhibits platelet function and thrombus formation through inducing internalization of platelet glycoprotein receptors.Journal of translational medicine · 2018Article
- NLRP3 regulates platelet integrin αIIbβ3 outside-in signaling, hemostasis and arterial thrombosis.Haematologica · 2018Article
- Phospholipid signaling in innate immune cells.The Journal of clinical investigation · 2018Review
- Single-platelet nanomechanics measured by high-throughput cytometry.Nature materials · 2017Article
- The inhibitory activity of ginsenoside Rp4 in adenosine diphosphate-induced platelet aggregation.Journal of ginseng research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
The integrin alpha(IIb)beta(3) plays a critical role in mediating clot retraction by platelets which is important in vivo in consolidating thrombus formation. Actin-myosin interaction is essential for clot retraction. In the present study, we demonstrate that the structurally distinct Src kinase inhibitors, PP2 and PD173952, significantly reduced the rate of clot retraction, but did not prevent it reaching completion. This effect was accompanied by abolition of alpha(IIb)beta(3)-dependent protein tyrosine phosphorylation, including PLCgamma2. A role for PLCgamma2 in mediating clot retraction was demonstrated using PLCgamma2-deficient murine platelets. Furthermore, platelet adhesion to fibrinogen leads to MLC phosphorylation through a pathway that is inhibited by PP2 and by the PLC inhibitor, U73122. These results demonstrate a partial role for Src kinase-dependent activation of PLCgamma2 and MLC phosphorylation in mediating clot retraction downstream of integrin alpha(IIb)beta(3).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.