ArticleMechanisms of development2007
Evidence for a cooperative role of gelatinase A and membrane type-1 matrix metalloproteinase during Xenopus laevis development.
Article in Mechanisms of development, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Matrix metalloproteinase 2 governs extracellular matrix remodeling during ovarian development in a viviparous teleost Sebastes schlegelii (Hilgendorf, 1880).BMC genomics · 2026Article
- Essential roles of YAP-TEAD complex in adult stem cell development during thyroid hormone-induced intestinal remodeling of Xenopus laevis.Cell and tissue research · 2022Article
- Analysis of Thyroid Hormone Receptor α-Knockout Tadpoles Reveals That the Activation of Cell Cycle Program Is Involved in Thyroid Hormone-Induced Larval Epithelial Cell Death and Adult Intestinal Stem Cell Development DuringThyroid : official journal of the American Thyroid Association · 2021Article
- Thyroid hormone-induced expression of Foxl1 in subepithelial fibroblasts correlates with adult stem cell development during Xenopus intestinal remodeling.Scientific reports · 2020Article
- Comprehensive RNA-Seq analysis of notochord-enriched genes induced during Xenopus tropicalis tail resorption.General and comparative endocrinology · 2020Article
- A unique role of thyroid hormone receptor β in regulating notochord resorption during Xenopus metamorphosis.General and comparative endocrinology · 2019Article
- Gene Expression Program Underlying Tail Resorption During Thyroid Hormone-Dependent Metamorphosis of the Ornamented Pygmy FrogFrontiers in endocrinology · 2019Article
- Remodelling the extracellular matrix in development and disease.Nature reviews. Molecular cell biology · 2014Review
- Activation of Sox3 gene by thyroid hormone in the developing adult intestinal stem cell during Xenopus metamorphosis.Endocrinology · 2014Article
- Article
- Functional characterization of tissue inhibitor of metalloproteinase-1 (TIMP-1) N- and C-terminal domains during Xenopus laevis development.TheScientificWorldJournal · 2014Article
- Differential regulation of two histidine ammonia-lyase genes during Xenopus development implicates distinct functions during thyroid hormone-induced formation of adult stem cells.Cell & bioscience · 2013Article
- Article
- Thyroid hormone-regulated expression of nuclear lamins correlates with dedifferentiation of intestinal epithelial cells during Xenopus laevis metamorphosis.Development genes and evolution · 2011Article
- Article
- Genome-wide identification of Xenopus matrix metalloproteinases: conservation and unique duplications in amphibians.BMC genomics · 2009Article
- Thyroid hormone-up-regulated hedgehog interacting protein is involved in larval-to-adult intestinal remodeling by regulating sonic hedgehog signaling pathway in Xenopus laevis.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- Article
- Matrix metalloproteinases and the regulation of tissue remodelling.Nature reviews. Molecular cell biology · 2007Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
Matrix metalloproteinases (MMPs) are a large family of extracellular or membrane-bound proteases. Their ability to cleave extracellular matrix (ECM) proteins has implicated a role in ECM remodeling to affect cell fate and behavior during development and in pathogenesis. We have shown previously that membrane-type 1 (MT1)-MMP [corrected] is coexpressed temporally and spatially with the MMP gelatinase A (GelA) in all cell types of the intestine and tail where GelA is expressed during Xenopus laevis metamorphosis, suggesting a cooperative role of these MMPs in development. Here, we show that Xenopus GelA and MT1-MMP interact with each other in vivo and that overexpression of MT1-MMP and GelA together in Xenopus embryos leads to the activation of pro-GelA. We further show that both MMPs are expressed during Xenopus embryogenesis, although MT1-MMP gene is expressed earlier than the GelA gene. To investigate whether the embryonic MMPs play a role in development, we have studied whether precocious expression of these MMPs alters development. Our results show that overexpression of both MMPs causes developmental abnormalities and embryonic death by a mechanism that requires the catalytic activity of the MMPs. More importantly, we show that coexpression of wild type MT1-MMP and GelA leads to a cooperative effect on embryonic development and that this cooperative effect is abolished when the catalytic activity of either MMP is eliminated through a point mutation in the catalytic domain. Thus, our studies support a cooperative role of these MMPs in embryonic development, likely through the activation of pro-GelA by MT1-MMP.
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