ArticleBrain, behavior, and immunity2007
Infection-induced proinflammatory cytokines are associated with decreases in positive affect, but not increases in negative affect.
Article in Brain, behavior, and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Dispositional optimism and stress-induced changes in immunity and negative mood.Brain, behavior, and immunity · 2009Trial
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- Neural and immune interactions linking early life stress and anhedonia.Brain, behavior, & immunity - health · 2024Article
- Stress to inflammation and anhedonia: Mechanistic insights from preclinical and clinical models.Neuroscience and biobehavioral reviews · 2023Review
- Sleep and Healthy Aging Research on Depression (SHARE-D) randomized controlled trial: Protocol overview of an experimental model of depression with insomnia, inflammation, and affect mechanisms in older adults.Brain, behavior, & immunity - health · 2023Article
- Article
- Association of serum interleukin-6 and C-reactive protein with depressive and adjustment disorders in COVID-19 inpatients.Brain, behavior, & immunity - health · 2022Article
- From childhood maltreatment to adult inflammation: Evidence for the mediational status of social anxiety and low positive affect.Brain, behavior, & immunity - health · 2021Article
- Sickness and sleep health predict frustration and affective responses to a frustrating trigger.Scientific reports · 2021Article
- Comparison of host immune responses to LPS in human using an immune profiling panel, in vivo endotoxemia versus ex vivo stimulation.Scientific reports · 2020Article
- Positive and Negative Affect and Salivary Markers of Inflammation Among Young Adults.International journal of behavioral medicine · 2020Article
- Family-based analyses reveal novel genetic overlap between cytokine interleukin-8 and risk for suicide attempt.Brain, behavior, and immunity · 2019Article
- Resilience and immunity.Brain, behavior, and immunity · 2018Review
- Emodiversity and biomarkers of inflammation.Emotion (Washington, D.C.) · 2018Article
- Sickness behavior in feverish children is independent of the severity of fever. An observational, multicenter study.PloS one · 2017Observational
- Socioeconomic status, daily affective and social experiences, and inflammation during adolescence.Psychosomatic medicine · 2015Article
- Bu-zhong-yi-qi pill alleviate the chemotherapy-related fatigue in 4 T1 murine breast cancer model.BMC complementary and alternative medicine · 2014Article
- Imipramine reverses depressive-like parameters in pneumococcal meningitis survivor rats.Journal of neural transmission (Vienna, Austria : 1996) · 2012Article
- C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- A critical review of human endotoxin administration as an experimental paradigm of depression.Neuroscience and biobehavioral reviews · 2010Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Infection commonly triggers nonspecific psychological and behavioral changes including fatigue and malaise, anhedonia, inability to concentrate, and disturbed sleep that collectively are termed "sickness behaviors". Converging evidence from several lines of research implicate the activities of proinflammatory cytokines as a cause of sickness behaviors. Here we elaborate upon the findings of previous research by examining whether infection-associated elevations in local proinflammatory cytokines are associated with increased negative mood and decreased positive mood. One hundred and eighty-nine healthy adults were experimentally exposed to rhinovirus or influenza virus during a 6-day period of quarantine. Infection, objective signs of illness, nasal IL-1beta, IL-6, and TNF-alpha, and self-reported affect were assessed at baseline and on each of the five post-challenge quarantine days. In the 153 persons who became infected following exposure to the challenge virus, daily production of IL-6, but not IL-1beta or TNF-alpha, was associated with reduced concurrent daily positive affect. One-day lagged analyses showed that daily production of all three cytokines was related to lower positive affect on the next day. All lagged associations were independent of previous-day positive affect and objective signs of illness (mucus production, mucociliary clearance function). There were no associations between cytokines and negative affect. Findings support a causal association between pathogen-induced local cytokine production and changes in positive affect over a 24-h timeline.
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Registered trials
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