Evidence map›Paper›PMID 1705479›Full record

ReviewCell biophysics1990

Leukocyte biophysics. An invited review.

G W Schmid-Schönbein

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cell biophysics, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
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  8. Article
  9. Molecular analysis of antigen-independent adhesion forces between T and B lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 1994
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

G W Schmid-SchönbeinDepartment of AMES-Bioengineering, University of California, San Diego, La Jolla 92093.

Funding

STRUCTURE/FUNCTION OF THE MICROCIRCULATIOMR01HL010881 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHMID-SCHOENBEIN, GEERT W. · 1985 to 2011
$3.1M
NHLBI NIH HHS HL-10881
6 · The paper itself

Abstract

The biophysical properties of leukocytes in the passive and active state are discussed. In the passive unstressed state, leukocytes are spherical with numerous membrane folds. Passive leukocytes exhibit viscoelastic properties, and the stress is carried largely by the cell cytoplasm and the nucleus. The membrane is highly deformable in shearing and bending, but resists area expansion. Membrane tension can usually be neglected but plays a role in cases of large deformation when the membrane becomes unfolded. The constant membrane area constraint is a determinant of phagocytic capacity, spreading of cells, and passage through narrow pores. In the active state, leukocytes undergo large internal cytoplasmic deformation, pseudopod projection, and granule redistribution. Several different measurements for assessment of biophysical properties and the internal cytoplasmic deformation in form of strain and strain rate tensors are presented. The current theoretical models for active cytoplasmic motion in leukocytes are discussed in terms of specific macromolecular reactions.

Indexed as

Biophysical PhenomenaBiophysicsCytoplasmHumansLeukocytesMathematicsMicroscopy, ElectronMicroscopy, Electron, Scanning

Identifiers

PMID1705479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.