Evidence map›Paper›PMID 17054395›Full record

ArticlePLoS pathogens2006

Anthrax toxin receptor 2-dependent lethal toxin killing in vivo.

Heather M Scobie, Darran J Wigelsworth, John M Marlett, Diane Thomas, G Jonah A Rainey, D Borden Lacy, Marianne Manchester, R John Collier, John A T Young

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS pathogens, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Anthrax toxin protective antigen--insights into molecular switching from prepore to pore.Protein science : a publication of the Protein Society · 2012
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Receptors of anthrax toxin and cell entry.Molecular aspects of medicine · 2009
    Review
  17. Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2009
    Article
  18. Article
  19. Article
  20. Pathophysiology of anthrax.Frontiers in bioscience (Landmark edition) · 2009
    Review
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Heather M ScobieInfectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America.
Darran J Wigelsworth
John M Marlett
Diane Thomas
G Jonah A Rainey
D Borden Lacy
Marianne Manchester
R John Collier
John A T Young
Salk Institute for Biological Studies · USHarvard University · USScripps Research Institute · US

Funding

Multivalent display of anthrax toxin inhibitorsP01AI056013 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI MANCHESTER, MARIANNE · 2003 to 2007
$9.2M
STRATEGIES TO INHIBIT CELLULAR UPTAKE OF ANTHRAX TOXINR01AI048489 · NIAID · UNIVERSITY OF WISCONSIN MADISON · PI YOUNG, JOHN A T · 2000 to 2008
$4.4M
NIAID NIH HHS AI48489NIAID NIH HHS AI56013NIAID NIH HHS P01 AI056013
6 · The paper itself

Abstract

Anthrax toxin receptors 1 and 2 (ANTXR1 and ANTXR2) have a related integrin-like inserted (I) domain which interacts with a metal cation that is coordinated by residue D683 of the protective antigen (PA) subunit of anthrax toxin. The receptor-bound metal ion and PA residue D683 are critical for ANTXR1-PA binding. Since PA can bind to ANTXR2 with reduced affinity in the absence of metal ions, we reasoned that D683 mutant forms of PA might specifically interact with ANTXR2. We show here that this is the case. The differential ability of ANTXR1 and ANTXR2 to bind D683 mutant PA proteins was mapped to nonconserved receptor residues at the binding interface with PA domain 2. Moreover, a D683K mutant form of PA that bound specifically to human and rat ANTXR2 mediated killing of rats by anthrax lethal toxin, providing strong evidence for the physiological importance of ANTXR2 in anthrax disease pathogenesis.

Indexed as

AnimalsAnthraxAntibodies, BacterialAntigens, BacterialBacillus anthracisBacterial ToxinsBase SequenceHumansLongevityMaleMembrane ProteinsMicrofilament ProteinsMolecular Sequence DataNeoplasm ProteinsRatsRats, Inbred F344anthrax toxinanthrax toxin receptorsAntibodies, BacterialAntigens, BacterialANTXR1 protein, humanANTXR2 protein, humanBacterial ToxinsMembrane ProteinsMicrofilament ProteinsNeoplasm ProteinsReceptors, Cell SurfaceReceptors, Peptide

Identifiers

PMID17054395
PMCPMC1617126
OpenAlexW2162178919

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.