ArticleNeurochemical research2006
Lobeline attenuates methamphetamine-induced stereotypy in adolescent mice.
Article in Neurochemical research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Pharmacological Treatments for Methamphetamine Use Disorder: Current Status and Future Targets.Substance abuse and rehabilitation · 2024Review
- Dissecting the Influence of Two Structural Substituents on the Differential Neurotoxic Effects of Acute Methamphetamine and Mephedrone Treatment on Dopamine Nerve Endings with the Use of 4-Methylmethamphetamine and Methcathinone.The Journal of pharmacology and experimental therapeutics · 2017Article
- Brain Histamine N-Methyltransferase As a Possible Target of Treatment for Methamphetamine Overdose.Drug target insights · 2016Review
- Pretreatment or Posttreatment with Aripiprazole Attenuates Methamphetamine-induced Stereotyped Behavior in Mice.Journal of experimental neuroscience · 2015Article
- The effects of lobeline and naltrexone on methamphetamine-induced place preference and striatal dopamine and serotonin levels in adolescent rats with a history of maternal separation.Metabolic brain disease · 2012Article
- Investigating Methamphetamine Craving Using the Extinction-Reinstatement Model in the Rat.Journal of addiction research & therapy · 2011Article
- Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse.Current topics in medicinal chemistry · 2011Review
- Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters.Bioorganic & medicinal chemistry · 2010Article
- Dose-dependent attenuation of heroin self-administration with lobeline.Journal of psychopharmacology (Oxford, England) · 2010Article
- Sigma1 receptor antagonists determine the behavioral pattern of the methamphetamine-induced stereotypy in mice.Psychopharmacology · 2009Article
- Modification of Monoaminergic Activity by MAO Inhibitors Influences Methamphetamine Actions.Drug target insights · 2006Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we investigated the effects of lobeline, an alkaloid constituent of Indian tobacco, on methamphetamine (METH)-induced stereotypy in male ICR mice (41-50 days old), an animal model for amphetamine psychosis. After a single administration of METH (10 mg/kg, i.p.), mice showed an initial short-lasting hyperlocomotion and subsequent stereotyped behaviors with a plateau level 25 min after drug challenge. Pretreatment with lobeline (3.0-30 mg/kg, i.p.) 15 min prior to the drug challenge significantly decreased the intensity of stereotypy and increased its latency to onset in a dose-dependent manner, especially 20 min after the drug challenge. In saline challenge groups, the doses of lobeline examined did not affect spontaneous locomotion nor induced any stereotyped behaviors. High-performance liquid chromatography analysis revealed that the range of lobeline doses examined except 30 mg/kg did not affect apparent monoamine turnover in the cerebral cortex, the region of the striatum and nucleus accumbens, and the region of the thalamus and hypothalamus of the mice 20 and 60 min after the drug challenge. These results suggested that the inhibitory effect of lobeline (3.0-10 mg/kg) on METH-induced stereotypy was not attributed to the change in the apparent monoamine turnover.
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Registered trials
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