Evidence map›Paper›PMID 17053895›Full record

Trial reportEuropean journal of clinical pharmacology2006

The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria.

Rose McGready, Kasia Stepniewska, Niklas Lindegardh, Elizabeth A Ashley, Yar La, Pratap Singhasivanon, Nicholas J White, François Nosten

Erratum issuedAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 59 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 8 pooled it
7.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 8 syntheses or guidelines pooled it, 118 citations in OpenAlex.

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4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Rose McGreadyShoklo Malaria Research Unit, P.O. Box 46, Mae Sot, Tak, Thailand.
Kasia Stepniewska
Niklas Lindegardh
Elizabeth A Ashley
Yar La
Pratap Singhasivanon
Nicholas J White
François Nosten
Mahidol Oxford Tropical Medicine Research Unit · THMahidol University · THShoklo Malaria Research Unit · THChurchill Hospital · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

objectiveTo determine the pharmacokinetic properties of artemether and lumefantrine (AL) in pregnant women with recrudescent uncomplicated multi-drug resistant falciparum malaria.

methodsPregnant women who had recurrence of parasitaemia following 7 days supervised quinine treatment were treated with AL. Serial blood samples were taken over a 7-day period, and pharmacokinetic parameters were estimated. For lumefantrine, these data were compared in a population pharmacokinetic model with data from non-pregnant, mainly male adults with acute malaria.

resultsThe pregnant women (five in the second trimester and eight in the third trimester) had lower concentrations of artemether, dihydroartemisinin and lumefantrine, and the elimination of lumefantrine in pregnant women was more rapid than reported previously in non-pregnant adults.

conclusionPregnancy is associated with reduced plasma concentrations of both artemether and lumefantrine. This is likely to be of therapeutic significance as plasma concentrations of lumefantrine, after elimination of artemether, are an important determinant of cure. Further studies are needed to determine the optimum dose regimen of artemether-lumefantrine in pregnancy.

Indexed as

AdolescentAdultAntimalarialsArea Under CurveArtemetherArtemisininsDrug Administration ScheduleEthanolaminesFemaleFluorenesFollow-Up StudiesHalf-LifeHumansLumefantrineMalaria, FalciparumMaleAntimalarialsArtemetherArtemisininsartenimolEthanolaminesFluorenesLumefantrineSesquiterpenesTablets

Identifiers

PMID17053895
OpenAlexW2069169531

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.