ArticleHuman genetics2007
Cytogenetically balanced translocations are associated with focal copy number alterations.
Article in Human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
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- Differentially expressed microRNAs in lung adenocarcinoma invert effects of copy number aberrations of prognostic genes.Oncotarget · 2018Article
- Emerging technologies in paediatric leukaemia.Translational pediatrics · 2015Review
- Recurring DNA copy number gain at chromosome 9p13 plays a role in the activation of multiple candidate oncogenes in progressing oral premalignant lesions.Cancer medicine · 2014Article
- Prostate cancer genetic-susceptibility locus on chromosome 20q13 is amplified and coupled to androgen receptor-regulation in metastatic tumors.Molecular cancer research : MCR · 2014Article
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- Inference of chromosome-specific copy numbers using population haplotypes.BMC bioinformatics · 2011Article
- Induction of human squamous cell-type carcinomas by arsenic.Journal of skin cancer · 2011Article
- Arsenic exposure and the induction of human cancers.Journal of toxicology · 2011Article
- Arsenic biotransformation as a cancer promoting factor by inducing DNA damage and disruption of repair mechanisms.Molecular biology international · 2011Article
- Arsenic-related DNA copy-number alterations in lung squamous cell carcinomas.British journal of cancer · 2010Article
- The finding of a reciprocal whole-arm translocation t(X;12)(p10;p10) in association with atypical chronic myeloid leukaemia.Medical oncology (Northwood, London, England) · 2010Article
- Array comparative genomic hybridization detects chromosomal abnormalities in hematological cancers that are not detected by conventional cytogenetics.The Journal of molecular diagnostics : JMD · 2010Article
- Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma.PLoS medicine · 2010Article
- The identification of chromosomal translocation, t(4;6)(q22;q15), in prostate cancer.Prostate cancer and prostatic diseases · 2010Article
- Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer.Cancer metastasis reviews · 2010Review
- Transcriptome profiles of carcinoma-in-situ and invasive non-small cell lung cancer as revealed by SAGE.PloS one · 2010Article
- Genetic tests to evaluate prognosis and predict therapeutic response in acute myeloid leukemia.The Journal of molecular diagnostics : JMD · 2010Review
- Cancer gene discovery in mouse and man.Biochimica et biophysica acta · 2009Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current cytogenetic methods (e.g., G-banding and multicolor chromosomal painting) allow detection of translocation events but lack the resolution to (a) locate the breakpoints precisely at the chromosome band level or (b) discriminate balanced translocations from translocations with copy number alterations not previously reported, or imperfectly balanced translocations. In this study, we demonstrate that cytogenetically balanced translocations are in fact frequently associated with segmental gain or loss of DNA. The recent development of a whole genome tiling path BAC array has enabled tiling resolution analysis of genomic segmental copy number status. Combining tiling resolution BAC array comparative genomic hybridization (array CGH) with G-Banding analysis and multicolor chromosomal painting approaches such as spectral karyotyping (SKY) facilitates high-resolution mapping of genomic alterations associated with imperfectly balanced translocations. Using a refined version of our CGH array we have deduced the copy number status throughout the genomes of three cytogenetically well-characterized prostate cancer cell lines (PC3, DU145, LNCaP) to determine whether translocations are associated with focal gains and losses of DNA. At 78 kb tiling resolution we identified the boundaries of 170, 80, and 34 known and novel copy number alterations (CNA) in these cell line genomes, respectively. Thirty-three of the 36 known translocations (92%, P < 0.001) in DU145 were associated with segmental CNA. Likewise, 80% (P < 0.001) of the known translocations showed association in LNCaP. Although many translocation breakpoints exhibit segmental alteration in PC3, the pattern of chromosomal rearrangements is too complex for use in comprehensive association with CNA boundaries. Our results reveal that imperfectly balanced translocations in tumor genomes are a phenomenon that occurs at frequencies much higher than previously demonstrated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.