ArticleJournal of muscle research and cell motility2006
Arginine supplementation induces myoblast fusion via augmentation of nitric oxide production.
Article in Journal of muscle research and cell motility, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Review
- Features of Fractal Conformity and Bioconsolidation in the Early Myogenesis Gene Expression and Their Relationship to the Genetic Diversity of Chicken Breeds.Animals : an open access journal from MDPI · 2023Article
- VEGFA rs2010963 GG genotype is associated with superior adaptations to resistance versus endurance training in the same group of healthy, young men.Molecular genetics and genomics : MGG · 2023Article
- L-Arginine/nitric oxide regulates skeletal muscle development via muscle fibre-specific nitric oxide/mTOR pathway in chickens.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Enhancing health span: muscle stem cells and hormesis.Biogerontology · 2022Review
- l-Arginine and Beetroot Extract Supplementation in the Prevention of Sarcopenia.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Unraveling signatures of chicken genetic diversity and divergent selection in breed-specific patterns of early myogenesis, nitric oxide metabolism and post-hatch growth.Frontiers in genetics · 2022Article
- l-Arginine Alleviates LPS-Induced Oxidative Stress and Apoptosis via Activating SIRT1-AKT-Nrf2 and SIRT1-FOXO3a Signaling Pathways in C2C12 Myotube Cells.Antioxidants (Basel, Switzerland) · 2021Article
- Arginine promotes myogenic differentiation and myotube formation through the elevation of cytoplasmic calcium concentration.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Article
- L-Arginine Enhances Protein Synthesis by Phosphorylating mTOR (Thr 2446) in a Nitric Oxide-Dependent Manner in C2C12 Cells.Oxidative medicine and cellular longevity · 2018Article
- Redox Control of Skeletal Muscle Regeneration.Antioxidants & redox signaling · 2017Review
- Novel microspheres reduce the formation of deep venous thrombosis and repair the vascular wall in a rat model.Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis · 2017Article
- L-Citrulline Protects Skeletal Muscle Cells from Cachectic Stimuli through an iNOS-Dependent Mechanism.PloS one · 2015Article
- Novel metabolic roles of L-arginine in body energy metabolism and possible clinical applications.The journal of nutrition, health & aging · 2014Article
- The effects of six weeks of supplementation with multi-ingredient performance supplements and resistance training on anabolic hormones, body composition, strength, and power in resistance-trained men.Journal of the International Society of Sports Nutrition · 2012Article
- An image analysis method for the precise selection and quantitation of fluorescently labeled cellular constituents: application to the measurement of human muscle cells in culture.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2012Article
- L-arginine intake effect on adenine nucleotide metabolism in rat parenchymal and reproductive tissues.TheScientificWorldJournal · 2012Article
- L-Arginine as a potential ergogenic aid in healthy subjects.Sports medicine (Auckland, N.Z.) · 2011Review
- Nitric oxide regulates stretch-induced proliferation in C2C12 myoblasts.Journal of muscle research and cell motility · 2010Article
- NF-kappaB functions in stromal fibroblasts to regulate early postnatal muscle development.The Journal of biological chemistry · 2010Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The semi-essential amino acid, L-arginine (L-Arg), is the substrate for endogenous synthesis of nitric oxide, a molecule that is involved in myoblast proliferation and fusion. Since L-Arg supply may limit nitric oxide synthase (NOS) activity in endothelial cells, we examined L-Arg supplementation in differentiating mouse myoblasts and tested the hypothesis that L-Arg exerts direct effects on myoblast fusion via augmentation of endogenous nitric oxide production. C(2)C(12) myoblasts in differentiation media received one of the following treatments for 120 h: 1 mM L-Arg, 0.1 mM N-nitro-L-arginine methyl ester (L-NAME), L-Arg + L-NAME, 10 mM L-Lysine, or no supplement (Control). Cultures were fixed and stained with hematoxylin and eosin for microphotometric image analysis of myotube density, nuclear density, and fusion index (% of total nuclei in myotubes). Endogenous production of nitric oxide during the treatment period peaked between 24 and 48 h. L-Arg amplified nitric oxide production between 0 and 24 h and increased myotube density, total nuclei number, and nuclear fusion index. These L-Arg effects were prevented by the NOS inhibitor, L-NAME. Further, L-Lysine, a competitive inhibitor of L-Arg uptake, repressed nitric oxide production and reduced myotube density and fusion index. In summary, L-Arg augments myotube formation and increases nitric oxide production in a process limited by cellular L-Arg uptake.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.