ArticleMolecular biology of the cell2006
Androgen-regulated formation and degradation of gap junctions in androgen-responsive human prostate cancer cells.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Degradation of cochlear Connexin26 accelerate the development of age-related hearing loss.Aging cell · 2023Article
- Article
- The roles of connexins and gap junctions in the progression of cancer.Cell communication and signaling : CCS · 2023Review
- Interception Targets ofCancer prevention research (Philadelphia, Pa.) · 2021Article
- Article
- Regulation of gap junction intercellular communication by connexin ubiquitination: physiological and pathophysiological implications.Cellular and molecular life sciences : CMLS · 2020Review
- Direct Intercellular Communications and Cancer: A Snapshot of the Biological Roles of Connexins in Prostate Cancer.Cancers · 2019Review
- Dileucine-like motifs in the C-terminal tail of connexin32 control its endocytosis and assembly into gap junctions.Journal of cell science · 2018Article
- The Complex Subtype-Dependent Role of Connexin 43 (GJA1) in Breast Cancer.International journal of molecular sciences · 2018Review
- Intramolecular signaling in a cardiac connexin: Role of cytoplasmic domain dimerization.Journal of molecular and cellular cardiology · 2017Article
- Regulation of Connexin43 Function and Expression by Tyrosine Kinase 2.The Journal of biological chemistry · 2016Article
- Analysis of connexin expression during seizures induced by 4-aminopyridine in the rat hippocampus.Journal of biomedical science · 2015Article
- The carboxyl tail of connexin32 regulates gap junction assembly in human prostate and pancreatic cancer cells.The Journal of biological chemistry · 2015Article
- TC-PTP directly interacts with connexin43 to regulate gap junction intercellular communication.Journal of cell science · 2014Article
- Vitamin D3 regulates the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells.PloS one · 2014Article
- Phosphorylation on Ser-279 and Ser-282 of connexin43 regulates endocytosis and gap junction assembly in pancreatic cancer cells.Molecular biology of the cell · 2013Article
- Minireview: regulation of gap junction dynamics by nuclear hormone receptors and their ligands.Molecular endocrinology (Baltimore, Md.) · 2012Review
- Degradation of connexins through the proteasomal, endolysosomal and phagolysosomal pathways.The Journal of membrane biology · 2012Review
- The role of connexins in prostate cancer promotion and progression.Nature reviews. Urology · 2012Review
- Retinoids regulate the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells.PloS one · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The constituent proteins of gap junctions, called connexins (Cxs), have a short half-life. Despite this, the physiological stimuli that control the assembly of Cxs into gap junctions and their degradation have remained poorly understood. We show here that in androgen-responsive human prostate cancer cells, androgens control the expression level of Cx32-and hence the extent of gap junction formation-post-translationally. In the absence of androgens, a major fraction of Cx32 is degraded presumably by endoplasmic reticulum-associated degradation, whereas in their presence, this fraction is rescued from degradation. We also show that Cx32 and Cx43 degrade by a similar mechanism. Thus, androgens regulate the formation and degradation of gap junctions by rerouting the pool of Cxs, which normally would have been degraded from the early secretory compartment, to the cell surface, and enhancing assembly into gap junctions. Androgens had no significant effect on the formation and degradation of adherens and tight junction-associated proteins. The findings that in a cell culture model that mimics the progression of human prostate cancer, degradation of Cxs, as well as formation of gap junctions, are androgen-dependent strongly implicate an important role of junctional communication in the prostate morphogenesis and oncogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.