ArticleMolecular biology of the cell2006
Proteasomal ubiquitin receptor RPN-10 controls sex determination in Caenorhabditis elegans.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
- Identification of BiP as a temperature sensor mediating temperature-induced germline sex reversal in C. elegans.The EMBO journal · 2024Article
- A novel endoplasmic reticulum adaptation is critical for the long-lived Caenorhabditis elegans rpn-10 proteasomal mutant.Biochimica et biophysica acta. Gene regulatory mechanisms · 2023Article
- Article
- Ubiquitin receptors play redundant roles in the proteasomal degradation of the p53 repressor MDM2.FEBS letters · 2022Article
- Proteasomal subunit depletions differentially affect germline integrity inFrontiers in cell and developmental biology · 2022Article
- Sex Determination in Nematode Germ Cells.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2022Review
- Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans.PLoS biology · 2021Article
- Differential Thresholds of Proteasome Activation Reveal Two Separable Mechanisms of Sensory Organ Polarization inFrontiers in cell and developmental biology · 2021Article
- Loss of proteasome subunit RPN-12 causes an increased mean lifespan at a higher temperature inmicroPublication biology · 2020Article
- Article
- Multi-modal regulation of C. elegans hermaphrodite spermatogenesis by the GLD-1-FOG-2 complex.Developmental biology · 2019Article
- Regulation of germ cell development by ARI1 family ubiquitin ligases in C. elegans.Scientific reports · 2018Article
- ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest.Biology open · 2018Article
- The C-terminal cytoplasmic tail of hedgehog receptor Patched1 is a platform for E3 ubiquitin ligase complexes.Molecular and cellular biochemistry · 2016Article
- Article
- The ubiquitin proteasome system in Caenorhabditis elegans and its regulation.Redox biology · 2014Review
- Development of Small Molecular Proteasome Inhibitors Using a Caenorhabditis elegans Screen.International journal of medicinal chemistry · 2014Article
- In vivo relevance of substrate recognition function of major Arabidopsis ubiquitin receptors.Plant signaling & behavior · 2012Article
- De Novo assembly of the Manila clam Ruditapes philippinarum transcriptome provides new insights into expression bias, mitochondrial doubly uniparental inheritance and sex determination.Molecular biology and evolution · 2012Article
- Deubiquitylation machinery is required for embryonic polarity in Caenorhabditis elegans.PLoS genetics · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ubiquitin-binding RPN-10 protein serves as a ubiquitin receptor that delivers client proteins to the 26S proteasome. Although ubiquitin recognition is an essential step for proteasomal destruction, deletion of the rpn-10 gene in yeast does not influence viability, indicating redundancy of the substrate delivery pathway. However, their specificity and biological relevance in higher eukaryotes is still enigmatic. We report herein that knockdown of the rpn-10 gene, but not any other proteasome subunit genes, sexually transforms hermaphrodites to females by eliminating hermaphrodite spermatogenesis in Caenorhabditis elegans. The feminization phenotype induced by deletion of the rpn-10 gene was rescued by knockdown of tra-2, one of sexual fate decision genes promoting female development, and its downstream target tra-1, indicating that the TRA-2-mediated sex determination pathway is crucial for the Delta rpn-10-induced sterile phenotype. Intriguingly, we found that co-knockdown of rpn-10 and functionally related ubiquitin ligase ufd-2 overcomes the germline-musculinizing effect of fem-3(gf). Furthermore, TRA-2 proteins accumulated in rpn-10-defective worms. Our results show that the RPN-10-mediated ubiquitin pathway is indispensable for control of the TRA-2-mediated sex-determining pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.