ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Role of bone morphogenic protein 2 in retinal patterning and retinotectal projection.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 58 citations in OpenAlex.
- Integration of in situ hybridization and scRNA-seq data provides a 2D topographical map of the developing retina across species.bioRxiv : the preprint server for biology · 2026Article
- Tbx genes influence early gene expression and photoreceptor patterning in the chick retina.bioRxiv : the preprint server for biology · 2025Article
- Myelin regulatory factor (MYRF) is a critical early regulator of retinal pigment epithelial development.PLoS genetics · 2025Article
- Molecular mechanisms controlling vertebrate retinal patterning, neurogenesis, and cell fate specification.Trends in genetics : TIG · 2023Review
- Changes in Expression in BMP2 and Two Closely Related Genes in Guinea Pig Retinal Pigment Epithelium during Induction and Recovery from Myopia.Biomolecules · 2023Article
- Heterogeneity in quiescent Müller glia in the uninjured zebrafish retina drive differential responses following photoreceptor ablation.Frontiers in molecular neuroscience · 2023Article
- Gene Expression Signatures of Contact Lens-Induced Myopia in Guinea Pig Retinal Pigment Epithelium.Investigative ophthalmology & visual science · 2022Article
- The Influence of Genetics in Myopia Control: A Pilot Study.Journal of clinical medicine · 2021Article
- Retinal Ganglion Cell Replacement: Current Status and Challenges Ahead.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Review
- Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) Regulates Retinal Axonal Projections by Inhibiting Eph and Abl Kinases in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Altered gene expression in tree shrew retina and retinal pigment epithelium produced by short periods of minus-lens wear.Experimental eye research · 2018Article
- Transitional Progenitors during Vertebrate Retinogenesis.Molecular neurobiology · 2017Review
- Effect of dopamine on bone morphogenesis protein-2 expression in human retinal pigment epithelium.International journal of ophthalmology · 2017Article
- Congenital Nystagmus Gene FRMD7 Is Necessary for Establishing a Neuronal Circuit Asymmetry for Direction Selectivity.Neuron · 2016Article
- Engrailed homeoproteins in visual system development.Cellular and molecular life sciences : CMLS · 2015Review
- SPIG1 negatively regulates BDNF maturation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Sma- and Mad-related protein 7 (Smad7) is required for embryonic eye development in the mouse.The Journal of biological chemistry · 2013Article
- Effects of imposed defocus of opposite sign on temporal gene expression patterns of BMP4 and BMP7 in chick RPE.Experimental eye research · 2013Article
- Extraocular ectoderm triggers dorsal retinal fate during optic vesicle evagination in zebrafish.Developmental biology · 2012Article
- Bidirectional, optical sign-dependent regulation of BMP2 gene expression in chick retinal pigment epithelium.Investigative ophthalmology & visual science · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been long believed that the anteroposterior (A-P) and dorsoventral (D-V) axes in the developing retina are determined independently and also that the retinotectal projection along the two axes is controlled independently. However, we recently demonstrated that misexpression of Ventroptin, a bone morphogenic protein (BMP) antagonist, in the developing chick retina alters the retinotectal projection not only along the D-V (or mediolateral) axis but also along the A-P axis. Moreover, the dorsal-high expression of BMP4 is relieved by the dorsotemporal-high expression of BMP2 at embryonic day 5 (E5) in the retina, during which Ventroptin continuously counteracts the two BMPs keeping on the countergradient expression pattern, respectively. Here, we show that the topographic molecules so far reported to have a gradient only along the D-V axis and ephrin-A2 so far only along the A-P axis are both controlled by the BMP signal, and that they are expressed in a gradient manner along the tilted axis from E6 on in the developing chick retina: the expression patterns of these oblique-gradient molecules are all changed, when BMP2 expression is manipulated in the developing retina. Furthermore, in both BMP2 knockdown embryos and ephrin-A2-misexpressed embryos, the retinotectal projection is altered along the two orthogonal axes. The expressional switching from BMP4 to BMP2 thus appears to play a key role in the retinal patterning and topographic retinotectal projection by tilting the D-V axis toward the posterior side during retinal development. Our results also indicate that BMP2 expression is essential for the maintenance of regional specificity along the revised D-V axis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.