ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Stereociliary myosin-1c receptors are sensitive to calcium chelation and absent from cadherin 23 mutant mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- PIPbioRxiv : the preprint server for biology · 2026Article
- Mitochondrial form and function in hair cells.Hearing research · 2023Review
- The role of motor proteins in photoreceptor protein transport and visual function.Ophthalmic genetics · 2022Article
- Functional Role of Class III Myosins in Hair Cells.Frontiers in cell and developmental biology · 2021Review
- The regulatory protein 14-3-3β binds to the IQ motifs of myosin-IC independent of phosphorylation.The Journal of biological chemistry · 2020Article
- The microRNA-183/96/182 Cluster is Essential for Stereociliary Bundle Formation and Function of Cochlear Sensory Hair Cells.Scientific reports · 2018Article
- Myosin-1c promotes E-cadherin tension and force-dependent recruitment of α-actinin to the epithelial cell junction.Journal of cell science · 2018Article
- Phosphoinositol-4,5-Bisphosphate Regulates Auditory Hair-Cell Mechanotransduction-Channel Pore Properties and Fast Adaptation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A Model for Link Pruning to Establish Correctly Polarized and Oriented Tip Links in Hair Bundles.Biophysical journal · 2017Article
- The molecules that mediate sensory transduction in the mammalian inner ear.Current opinion in neurobiology · 2015Review
- Functional mechanotransduction is required for cisplatin-induced hair cell death in the zebrafish lateral line.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Integrating the biophysical and molecular mechanisms of auditory hair cell mechanotransduction.Nature communications · 2011Review
- Calmodulin dissociation regulates Myo5 recruitment and function at endocytic sites.The EMBO journal · 2010Article
- Development and regeneration of sensory transduction in auditory hair cells requires functional interaction between cadherin-23 and protocadherin-15.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Review
- Tip links in hair cells: molecular composition and role in hearing loss.Current opinion in otolaryngology & head and neck surgery · 2009Review
- MAGI-1, a candidate stereociliary scaffolding protein, associates with the tip-link component cadherin 23.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Aminoglycoside-induced phosphatidylserine externalization in sensory hair cells is regionally restricted, rapid, and reversible.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Cadherins and mechanotransduction by hair cells.Current opinion in cell biology · 2008Review
- Auditory transduction in the mouse.Pflugers Archiv : European journal of physiology · 2007Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The identities of some of the constituents of the hair-cell transduction apparatus have been elucidated only recently. The molecular motor myosin-1c (Myo1c) functions in adaptation of the hair-cell response to sustained mechanical stimuli and is therefore an integral part of the transduction complex. Recent data indicate that Myo1c interacts in vitro with two other molecules proposed to be important for transduction: cadherin 23 (Cdh23), a candidate for the stereociliary tip link, and phosphatidylinositol 4,5-bisphosphate (PIP2), which is abundant in the membranes of hair-cell stereocilia. It is not known, however, whether these interactions occur in hair cells. Using an in situ binding assay on saccular hair cells, we demonstrated previously that Myo1c interacts with molecules at stereociliary tips, the site of transduction, through sequences contained within its calmodulin (CaM)-binding neck domain, which can bind up to four CaM molecules. In the current study, we identify the second CaM-binding IQ domain as a region of Myo1c that mediates CaM-sensitive binding to stereociliary tips and to PIP2 immobilized on a solid support. Binding of Myo1c to stereociliary tips of cochlear and vestibular hair cells is disrupted by treatments that break tip links. In addition, Myo1c does not bind to stereocilia from mice whose hair cells lack Cdh23 protein despite the presence of PIP2 in the stereociliary membranes. Collectively, our data suggest that Myo1c and Cdh23 interact at the tips of hair-cell stereocilia and that this interaction is modulated by CaM.
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