ArticleGenes & development2006
Metastatic tumor antigen 3 is a direct corepressor of the Wnt4 pathway.
Article in Genes & development, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 61 citations in OpenAlex.
- Mechanisms of MTA3 in cancer and related diseases and its clinical applications.Frontiers in oncology · 2025Review
- Genetic variants associated with spontaneous preterm birth in women from India: a prospective cohort study.The Lancet regional health. Southeast Asia · 2023Article
- The effect of progesterone administration on the expression of metastasis tumor antigens (MTA1 and MTA3) in placentas of normal and dexamethasone-treated rats.Molecular biology reports · 2022Article
- Article
- MTA3-SOX2 Module Regulates Cancer Stemness and Contributes to Clinical Outcomes of Tongue Carcinoma.Frontiers in oncology · 2019Article
- The oncogenic roles of nuclear receptor coactivator 1 in human esophageal carcinoma.Cancer medicine · 2018Article
- AMP-activated protein kinase promotes epithelial-mesenchymal transition in cancer cells through Twist1 upregulation.Journal of cell science · 2018Article
- Metastasis-associated protein 3 in colorectal cancer determines tumor recurrence and prognosis.Oncotarget · 2017Article
- Corepressor metastasis-associated protein 3 modulates epithelial-to-mesenchymal transition and metastasis.Chinese journal of cancer · 2017Review
- PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2.Oncogene · 2017Article
- WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines.Breast cancer research : BCR · 2016Article
- Review
- Genistein alleviates pressure overload-induced cardiac dysfunction and interstitial fibrosis in mice.British journal of pharmacology · 2015Article
- [Regulation Mechanism of MTA3 in the Apoptosis of NSCLC Cells].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2015Article
- Expression of metastasis-associated protein 3 in human brain glioma related to tumor prognosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Article
- Structure and function insights into the NuRD chromatin remodeling complex.Cellular and molecular life sciences : CMLS · 2015Review
- The nucleosome remodeling and deacetylase complex in development and disease.Translational research : the journal of laboratory and clinical medicine · 2015Review
- Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway.Autophagy · 2015Article
- Physiological functions of MTA family of proteins.Cancer metastasis reviews · 2014Review
- Regulation of mammary epithelial cell homeostasis by lncRNAs.The international journal of biochemistry & cell biology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Here we show that expression of MTA3 inhibits ductal branching in virgin and pregnant murine transgenic mammary glands. MTA3 also suppresses the Wnt4 pathway and, thus, these findings parallel phenotypic changes in Wnt4-null mice. MTA3 represses Wnt4 transcription and Wnt4 secretion, inhibiting Wnt-target genes in mammary epithelial cells. Accordingly, knockdown of endogenous MTA3 stimulates Wnt4 expression and Wnt cellular targets. The MTA3-NuRD (nucleosome remodeling and deacetylase) complex physically interacts with the Wnt4 chromatin in an HDAC-dependent manner, leading to suppression of the Wnt4 gene and Wnt4-dependent morphogenesis. These findings identify MTA3 as an upstream physiologic repressor of Wnt4 in mammary epithelial cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.