ArticleGenomics2007
Signatures from tissue-specific MPSS libraries identify transcripts preferentially expressed in the mouse inner ear.
Article in Genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Cochlear transcript diversity and its role in auditory functions implied by an otoferlin short isoform.Nature communications · 2023Article
- Profiling mouse cochlear cell maturation using 10× Genomics single-cell transcriptomics.Frontiers in cellular neuroscience · 2022Article
- Anosmin-1-Like Effect of UMODL1/Olfactorin on the Chemomigration of Mouse GnRH Neurons and Zebrafish Olfactory Axons Development.Frontiers in cell and developmental biology · 2022Article
- Genome-wide identification of directed gene networks using large-scale population genomics data.Nature communications · 2018Article
- High-resolution transcriptional dissection of in vivo Atoh1-mediated hair cell conversion in mature cochleae identifies Isl1 as a co-reprogramming factor.PLoS genetics · 2018Article
- ILDR1 null mice, a model of human deafness DFNB42, show structural aberrations of tricellular tight junctions and degeneration of auditory hair cells.Human molecular genetics · 2015Article
- Article
- A null mutation of mouse Kcna10 causes significant vestibular and mild hearing dysfunction.Hearing research · 2013Article
- Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii.Nature communications · 2013Article
- Overexpression of Uromodulin-like1 accelerates follicle depletion and subsequent ovarian degeneration.Cell death & disease · 2012Article
- USH1K, a novel locus for type I Usher syndrome, maps to chromosome 10p11.21-q21.1.Journal of human genetics · 2012Article
- Actin in hair cells and hearing loss.Hearing research · 2012Review
- UMARS: Un-MAppable Reads Solution.BMC bioinformatics · 2011Article
- Loss-of-function mutations of ILDR1 cause autosomal-recessive hearing impairment DFNB42.American journal of human genetics · 2011Article
- Discovery and characterization of medaka miRNA genes by next generation sequencing platform.BMC genomics · 2010Article
- DFNB79: reincarnation of a nonsyndromic deafness locus on chromosome 9q34.3.European journal of human genetics : EJHG · 2010Article
- Identifying components of the hair-cell interactome involved in cochlear amplification.BMC genomics · 2009Article
- USH1H, a novel locus for type I Usher syndrome, maps to chromosome 15q22-23.Clinical genetics · 2009Article
- Efficient targeted transcript discovery via array-based normalization of RACE libraries.Nature methods · 2008Article
- Glucose transporter 5 is undetectable in outer hair cells and does not contribute to cochlear amplification.Brain research · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Specialization in cell function and morphology is influenced by the differential expression of mRNAs, many of which are expressed at low abundance and restricted to certain cell types. Detecting such transcripts in cDNA libraries may require sequencing millions of clones. Massively parallel signature sequencing (MPSS) is well suited to identifying transcripts that are expressed in discrete cell types and in low abundance. We have made MPSS libraries from microdissections of three inner ear tissues. By comparing these MPSS libraries to those of 87 other tissues included in the Mouse Reference Transcriptome online resource, we have identified genes that are highly enriched in, or specific to, the inner ear. We show by RT-PCR and in situ hybridization that signatures unique to the inner ear libraries identify transcripts with highly specific cell-type localizations. These transcripts serve to illustrate the utility of a resource that is available to the research community. Utilization of these resources will increase the number of known transcription units and expand our knowledge of the tissue-specific regulation of the transcriptome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.