ArticleHistochemistry1990
Capillary area in early low-dose streptozocin-treated mice.
Article in Histochemistry, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Diabetes as a Pancreatic Microvascular Disease-A Pericytic Perspective.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2024Review
- Review
- Pancreatic duct inflammatory infiltration in the nonobese diabetic (NOD) mouse.Journal of anatomy · 1994Article
- Intercellular adhesion molecule-1 (ICAM-1) expression in the islets of the non-obese diabetic and low-dose streptozocin-treated mouse.Histochemistry · 1994Article
- An increase in superoxide dismutase counteracts islet vascular alterations in low-dose streptozocin-treated mice.Histochemistry · 1994Article
- Early insulitis and the islet vascular system.Diabetologia · 1993Article
- Morphological observations on pancreatic islet blood vessels in low-dose streptozocin-treated mice.Journal of anatomy · 1993Article
- Increased vascular permeability in pancreas of diabetic rats: detection with high resolution protein A-gold cytochemistry.Diabetologia · 1992Article
- Oxygen radicals generated by the enzyme xanthine oxidase lyse rat pancreatic islet cells in vitro.Diabetologia · 1992Article
- Alterations of islet microvasculature in mice treated with low-dose streptozocin.Histochemistry · 1992Article
- Ultrastructural observations on cytotoxic effector cells infiltrating pancreatic islets of low-dose streptozocin treated mice.Virchows Archiv. A, Pathological anatomy and histopathology · 1992Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been reported that vasoconstriction of intra-islet capillaries plays an important role in the initiation of the insulitis seen in the islets of Langerhans of diabetic animals. Nevertheless, only a few studies have concentrated on islet vessels. This led us to perform an experiment with the aim to compare the islet capillary area of normal untreated and multiple low-dose streptozocin (LDS) (40 mg/kg b.wt. i.p./5 days)-treated mice. In order to identify endothelial cells a method devised by Gomori, based on the fact that these cells present alkaline phosphatases on their surface, was used. Results revealed that in LDS-treated animals the capillary area per islet is significantly reduced when compared to the vascular area of controls (p less than 0.05). This could be due to a vasoconstriction phenomenon that occurs in the islet capillaries after the streptozocin administration and before the appearance of any inflammation. Our findings could demonstrate that vasoconstriction events are involved in initiation of the diabetic disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.