ReviewCurrent topics in microbiology and immunology2006
The privacy of T cell memory to viruses.
Review in Current topics in microbiology and immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Tolerization with a Novel Dual-Acting Liposomal Tim Agonist Prepares the Immune System for the Success of Gene Therapy.International journal of molecular sciences · 2025Article
- Cross-reactivity influences changes in human influenza A virus and Epstein Barr virus specific CD8 memory T cell receptor alpha and beta repertoires between young and old.Frontiers in immunology · 2022Article
- Article
- Vaccination and heterologous immunity: educating the immune system.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2015Review
- Cross reactive cellular immune response to HCV genotype 1 and 4 antigens among genotype 4 exposed subjects.PloS one · 2014Article
- Mathematical models of memory CD8+ T-cell repertoire dynamics in response to viral infections.Bulletin of mathematical biology · 2013Article
- Experimental autoimmune encephalomyelitis as a testing paradigm for adjuvants and vaccines.Vaccine · 2011Review
- Cross-reactivity and expansion of dengue-specific T cells during acute primary and secondary infections in humans.Scientific reports · 2011Article
- Bi-specific MHC heterodimers for characterization of cross-reactive T cells.The Journal of biological chemistry · 2010Article
- High content cellular immune profiling reveals differences between rhesus monkeys and men.Immunology · 2010Article
- Studies in the modulation of experimental autoimmune encephalomyelitis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Review
- Heterologous immunity between viruses.Immunological reviews · 2010Review
- Pathological features of heterologous immunity are regulated by the private specificities of the immune repertoire.The American journal of pathology · 2010Article
- A systematic approach to virus-virus interactions.Virus research · 2010Review
- CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Effects of acute and chronic murine norovirus infections on immune responses and recovery from Friend retrovirus infection.Journal of virology · 2009Article
- Adaptive immunity to hepatitis C virus.Viruses · 2009Article
- Asymptomatic human CD4+ cytotoxic T-cell epitopes identified from herpes simplex virus glycoprotein B.Journal of virology · 2008Article
- Gender-dependent HLA-DR-restricted epitopes identified from herpes simplex virus type 1 glycoprotein D.Clinical and vaccine immunology : CVI · 2008Article
- Pathogenic epitopes, heterologous immunity and vaccine design.Nature reviews. Microbiology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
T cell responses to viral infections can mediate either protective immunity or damaging immunopathology. Viral infections induce the proliferation of T cells specific for viral antigens and cause a loss in the number of T cells with other specificities. In immunologically naive hosts, viruses will induce T cell responses that, dependent on the MHC, recognize a distinct hierarchy of virus-encoded T cell epitopes. This hierarchy can change if the host has previously encountered another pathogen that elicited a memory pool ofT cells specific to a cross-reactive epitope. This heterologous immunity can deviate the normal immune response and result in either beneficial or harmful effects on the host. Each host has a unique T cell repertoire caused by the random DNA rearrangement that created it, so the specific T cells that create the epitope hierarchy differ between individuals. This "private specificity" seems of little significance in the T cell response of a naive host to infection, but it is of profound importance under conditions of heterologous immunity, where a small subset of a cross-reactive memory pool may expand and dominate a response. Examples are given of how the private specificities of immune responses under conditions of heterologous immunity influence the pathogenesis of murine and human viral infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.