ArticleImmunogenetics2006
Analysis of single nucleotide polymorphisms at 13 loci within the transforming growth factor-induced factor gene shows no association with high myopia in Japanese subjects.
Article in Immunogenetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Myopia Genetics and Heredity.Children (Basel, Switzerland) · 2022Review
- Update on Myopia Risk Factors and Microenvironmental Changes.Journal of ophthalmology · 2019Review
- Insight into the molecular genetics of myopia.Molecular vision · 2017Review
- The association of a single nucleotide polymorphism in the promoter region of the LAMA1 gene with susceptibility to Chinese high myopia.Molecular vision · 2011Article
- Fine mapping linkage analysis identifies a novel susceptibility locus for myopia on chromosome 2q37 adjacent to but not overlapping MYP12.Molecular vision · 2009Article
- Myocilin polymorphisms and high myopia in subjects of European origin.Molecular vision · 2009Article
- Molecular genetics of human myopia: an update.Optometry and vision science : official publication of the American Academy of Optometry · 2009Article
- Evaluation of EGR1 as a candidate gene for high myopia.Molecular vision · 2008Article
- Lack of association with high myopia and the MYP2 locus in the Japanese population by high resolution microsatellite analysis on chromosome 18.Clinical ophthalmology (Auckland, N.Z.) · 2007Article
- A novel G26A variation in 5' half of TGIF1 gene associates with high myopia in ethnic Kashmiri population from India.Taiwan journal of ophthalmologyArticle
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Authors and funding
13 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A previous study in China first indicated that the transforming growth factor-induced factor (TGIF) is a probable candidate gene for high myopia. The purpose of our study was to investigate whether there are significant associations between high myopia and single nucleotide polymorphism (SNP) variants in the TGIF gene of Japanese subjects. Genomic DNA was collected from 330 Japanese subjects with high myopia and at a level refractive error was less than -9.25 Dsph and 330 randomized controls without high myopia. Thirteen SNPs were detected by polymerase chain reaction (PCR) and primer extension or by PCR and SNP-specific fluorogenic probes in all of the cases and controls. Thirteen SNPs were found within the TGIF genes of the cases and controls. Two of the SNPs were monomorphic and none of the 13 SNPs showed a significant result. The pairwise linkage disequilibrium (LD) mapping confirmed that these alleles have a comparatively strong LD index of >0.8 for D' and >0.4 for r(2). We found no statistical association between any of the 13 SNPs located on the TGIF gene and high myopia in Japanese subjects. Based on our study using Japanese subjects and the previous studies of TGIF gene polymorphism in Chinese and northern European subjects with myopia, there is no convincing evidence to prove a connection between nucleotide sequence variations in TGIF and high myopia.
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