ArticlePsychopharmacology2006
Ethanol exposure differentially alters pro-enkephalin mRNA expression in regions of the mesocorticolimbic system.
Article in Psychopharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- The role of enkephalinergic systems in substance use disorders.Frontiers in systems neuroscience · 2022Review
- Episodic Ethanol Exposure in Adolescent Rats Causes Residual Alterations in Endogenous Opioid Peptides.Frontiers in psychiatry · 2018Article
- Delta Opioid Pharmacology in Relation to Alcohol Behaviors.Handbook of experimental pharmacology · 2018Review
- Alcohol and basal ganglia circuitry: Animal models.Neuropharmacology · 2017Review
- Mu-opioid receptor activation in the medial shell of nucleus accumbens promotes alcohol consumption, self-administration and cue-induced reinstatement.Neuropharmacology · 2016Article
- Effects of an opioid (proenkephalin) polymorphism on neural response to errors in health and cocaine use disorder.Behavioural brain research · 2015Article
- Endogenous opioids as substrates for ethanol intake in the neonatal rat: The impact of prenatal ethanol exposure on the opioid family in the early postnatal period.Physiology & behavior · 2015Article
- The opioid receptors as targets for drug abuse medication.British journal of pharmacology · 2015Review
- Adenosine signaling in striatal circuits and alcohol use disorders.Molecules and cells · 2013Review
- Acute ethanol administration differentially alters enkephalinase and aminopeptidase N activity and mRNA levels in regions of the nigrostriatal pathway.Journal of molecular neuroscience : MN · 2013Article
- Disturbances in behavior and cortical enkephalin gene expression during the anticipation of ethanol in rats characterized as high drinkers.Alcohol (Fayetteville, N.Y.) · 2012Article
- δ-opioid receptor function in the dorsal striatum plays a role in high levels of ethanol consumption in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Neurobiology of consummatory behavior: mechanisms underlying overeating and drug use.ILAR journal · 2012Review
- Activity and expression of enkephalinase and aminopeptidase N in regions of the mesocorticolimbic system are selectively modified by acute ethanol administration.Journal of molecular neuroscience : MN · 2012Article
- Regulation of drug and palatable food overconsumption by similar peptide systems.Current drug abuse reviews · 2011Review
- Similarities in hypothalamic and mesocorticolimbic circuits regulating the overconsumption of food and alcohol.Physiology & behavior · 2011Review
- Opioid receptors and the discriminative stimulus effects of ethanol in squirrel monkeys: Mu and delta opioid receptor mechanisms.European journal of pharmacology · 2011Article
- Effect of chronic ethanol on enkephalin in the hypothalamus and extra-hypothalamic areas.Alcoholism, clinical and experimental research · 2010Article
- Ethanol-induced changes in proenkephalin mRNA expression in the rat nigrostriatal pathway.Journal of molecular neuroscience : MN · 2008Article
- Endogenous opiates and behavior: 2006.Peptides · 2007Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleOpioid peptides have been suggested to play a major role in ethanol reinforcement mechanisms and alcohol drinking behaviour. However, in non-selected strains of rodents, it is not known whether opioid biosynthesis is a critical event in these processes.
objectiveThe aim of this work was to study the effects of a high dose of ethanol (2.5 g/kg body weight) on pro-enkephalin (pro-enk) mRNA expression in brain regions of the mesocorticolimbic system for up to 24 h after drug administration. MATERIALS AND
methodsMale Wistar rats were administered with ethanol (2.5 g/kg body weight) or distilled water and were killed 30 min, 1, 2, 4, 8 or 24 h after treatment. Coronal brain sections (20 mu) were obtained and pro-enk mRNA expression was studied by in situ hybridization and densitometry.
resultsAcute ethanol administration induced a transient decrease and increase in pro-enk mRNA expression in the ventral tegmental area (33.2%) and prefrontal cortex (26.5%) 2 and 4 h after treatment, respectively. In contrast, ethanol induced prolonged increases in pro-enk mRNA expression in the core and shell regions of the nucleus accumbens, with different kinetics. Maximal effects were observed 2 h after ethanol exposure (core, 70.0%; shell, 60.0%).
conclusionsOur results indicate that enkephalin expression in regions of the rat mesocorticolimbic system is differentially altered by acute ethanol treatment and suggest that enkephalins may play a key role in ethanol reinforcement mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.