ArticlePsychopharmacology2007
Binge ethanol administration enhances the MDMA-induced long-term 5-HT neurotoxicity in rat brain.
Article in Psychopharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Hard Boiled: Alcohol Use as a Risk Factor for MDMA-Induced Hyperthermia: a Systematic Review.Neurotoxicity research · 2021Pooled it
- Patterns and Mood Effects of Concomitant Polydrug Use of Ecstasy and Alcohol in Dutch and British Electronic Dance Event Visitors: An EMA Study.European addiction research · 2026Article
- Alcohol Co-Administration Changes Mephedrone-Induced Alterations of Neuronal Activity.Frontiers in pharmacology · 2021Article
- Neuronal and peripheral damages induced by synthetic psychoactive substances: an update of recent findings from human and animal studies.Neural regeneration research · 2020Review
- Binge Ethanol and MDMA Combination Exacerbates Toxic Cardiac Effects by Inducing Cellular Stress.PloS one · 2015Article
- Article
- Aromatic Amines Exert Contrasting Effects on the Anticoagulant Effect of Acetaldehyde upon APTT.Advances in hematology · 2014Article
- Behavioural and neuroinflammatory effects of the combination of binge ethanol and MDMA in mice.Psychopharmacology · 2012Article
- Increased oxidative-modifications of cytosolic proteins in 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-exposed rat liver.Proteomics · 2011Article
- Mechanisms of MDMA (ecstasy)-induced oxidative stress, mitochondrial dysfunction, and organ damage.Current pharmaceutical biotechnology · 2010Review
- Drug interaction between ethanol and 3,4-methylenedioxymethamphetamine ("ecstasy").Toxicology letters · 2009Article
- Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: an overview.Molecular neurobiology · 2009Review
- The effect of long-term repeated exposure to 3,4-methylenedioxymethamphetamine on cardiovascular and thermoregulatory changes.Psychopharmacology · 2008Article
- Interactions between ethanol and cocaine, amphetamine, or MDMA in the rat: thermoregulatory and locomotor effects.Psychopharmacology · 2008Article
- Ethanol and MDMA: a comment on the paper by Izco et al.Psychopharmacology · 2007Article
- Factors contributing to the enhancement of MDMA-induced 5-HT depletion by ethanol: a reply to Byron and Cassel.Psychopharmacology · 2007Article
- The variety of ecstasy/MDMA users: results from the National Epidemiologic Survey on alcohol and related conditions.The American journal on addictionsArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleEcstasy abuse commonly occurs in hot, overcrowded environments in combination with alcohol. Around 90% of ecstasy users take ethanol; over 70% of these users also often drink alcohol at hazardous levels.
objectivesWe wished to examine whether binge ethanol administration enhanced the long-lasting 5-HT neurotoxicity induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats maintained at high ambient temperature and the role of acetaldehyde. MATERIALS AND
methodsRats were treated with a 4-day ethanol regimen leading to plasma ethanol levels of around 450 mg/dl. On day 5, rats were placed at 30 degrees C and administered MDMA (5 mg/kg). Rectal temperature and hydroxyl radical formation were measured immediately before and up to 6 h after MDMA. 5-HT concentration and 5-HT transporter density were determined 7 days later. A group of rats received cyanamide (50 mg/kg) on days 1 and 3 of the 4-day-ethanol inhalation.
resultsIn ethanol treated rats, MDMA produced a hyperthermic response similar to that observed in controls but enhanced the loss of 5-HT concentration and 5-HT transporter density in the hippocampus. Cyanamide elevated the plasma acetaldehyde concentration fivefold to sevenfold, reduced the MDMA-induced hyperthermia and increased the neuronal damage with neurotoxicity also appearing in the cortex. MDMA increased hydroxyl radical production in the hippocampus, the effect being more marked in rats pre-exposed to ethanol.
conclusionsBinge ethanol administration enhances the MDMA-induced long-term 5-HT neurotoxicity by a mechanism not related to changes in acute hyperthermia but probably involving hydroxyl radical formation. The magnitude of this effect is more pronounced after increasing plasma acetaldehyde levels by aldehyde dehydrogenase inhibition.
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